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Literature summary for 3.4.21.B7 extracted from

  • Rossi, V.; Cseh, S.; Bally, I.; Thielens, N.M.; Jensenius, J.C.; Arlaud, G.J.
    Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2 (2001), J. Biol. Chem., 276, 40880-40887.
    View publication on PubMed
Search for more literature for 3.4.21.B7

Cloned(Commentary)

Cloned (Comment) Organism
mature protein and truncated fragments Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
C1 inhibitor abolishes activity at a 1:1 inhibitor:protease concentration Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.18
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
0.31
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens
34000
-
 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens
50000
-
 SDS-PAGE, non-reducing conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in innate immunity ?
-
 ?
Protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
complement component C3 + H2O
-
 Homo sapiens ?
-
 ?
additional information no activity with complement C4 Homo sapiens ?
-
 ?
additional information involved in innate immunity Homo sapiens ?
-
 ?
N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester + H2O
-
 Homo sapiens ?
-
 ?
Nalpha-benzoyl-L-arginine ethyl ester + H2O
-
 Homo sapiens ?
-
 ?
Protein + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions Homo sapiens

Synonyms

Synonyms Comment Organism
MASP-1
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
 Nalpha-benzoyl-L-arginine ethyl ester pH 7.4, 30°C Homo sapiens
1.23
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens
6.08
-
 N-carboxybenzyloxyglycine-L-arginine thiobenzyl ester pH 7.4, 30°C Homo sapiens