Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C1-inhibitor | forms a complex with MASP-1 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
1 * 70000 + 1 * 29000, activated form | Mus musculus |
31000 | - |
1 * 66000 + 1 * 31000, activated form | Homo sapiens |
66000 | - |
1 * 66000 + 1 * 31000, activated form | Homo sapiens |
70000 | - |
1 * 70000 + 1 * 29000, activated form | Mus musculus |
93000 | - |
unactivated proenzyme | Homo sapiens |
100000 | - |
unactivated proenzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | involved in activation of complement cascade, forms a complex with mannose-binding lectin | ? | - |
? | |
additional information | Homo sapiens | involved in activation of complement cascade, forms a complex with mannose-binding lectin | ? | - |
? | |
Protein + H2O | Mus musculus | - |
? | - |
? | |
Protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | unactivated proenzyme is converted into the active form comprised of two polypeptides by cleavage between Arg448 and Ile449 | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C2 + H2O | activates complement C2 | Homo sapiens | ? | - |
? | |
complement component C3 + H2O | activates complement C3 | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
additional information | involved in activation of complement cascade, forms a complex with mannose-binding lectin | Mus musculus | ? | - |
? | |
additional information | involved in activation of complement cascade, forms a complex with mannose-binding lectin | Homo sapiens | ? | - |
? | |
Protein + H2O | - |
Mus musculus | ? | - |
? | |
Protein + H2O | - |
Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 66000 + 1 * 31000, activated form | Homo sapiens |
dimer | 1 * 70000 + 1 * 29000, activated form | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
MASP-1 | - |
Homo sapiens |
P100 | - |
Mus musculus |
P100 | - |
Homo sapiens |
RaRF | complex of the enzyme with mannose-binding lectin | Homo sapiens |