Activating Compound | Comment | Organism | Structure |
---|---|---|---|
CHAPS | increases enzyme activity up to 4fold with increasing concentration | Homo sapiens | |
DMSO | increases enzyme activity up to 2fold with increasing concentration | Homo sapiens | |
additional information | NP-40, Triton X-100, 15% glycerol, up to 0.5 mM DTT and 0.25 mM beta-mercaptoethanol have no effect on enzyme activity | Homo sapiens | |
ZnCl2 | with acetyl-PRLR-7-amino-3-carbamoylmethyl-4-methylcoumarin | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Sf9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aprotinin | - |
Homo sapiens | |
Brij 35 | activity decreases with increasing detergent concentration | Homo sapiens | |
CaCl2 | - |
Homo sapiens | |
CoCl2 | - |
Homo sapiens | |
CuCl2 | - |
Homo sapiens | |
EDTA | reduces enzyme activity by 30% | Homo sapiens | |
LiCl | - |
Homo sapiens | |
MgCl2 | - |
Homo sapiens | |
additional information | not inhibited by alpha1-antitrypsin, alpha1-antitrypsinPDX, alpha1-antichymotrypsin, and soybean trypsin inhibitor | Homo sapiens | |
NaCl | - |
Homo sapiens | |
NaF | - |
Homo sapiens | |
NaI | - |
Homo sapiens | |
NiCl2 | - |
Homo sapiens | |
placental bikunin | - |
Homo sapiens | |
Tween 20 | activity decreases with increasing detergent concentration | Homo sapiens | |
ZnCl2 | with acetyl-KHYR-7-amino-3-carbamoylmethyl-4-methylcoumarin | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0555 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
0.0786 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
0.141 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
0.193 | - |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
0.219 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
0.86 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
SDS-PAGE, glycosylated enzyme | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-amido-4-carbamoylmethylcoumarin-KHYRSVAS-K(DNP)R + H2O | - |
Homo sapiens | ? | - |
? | |
7-amido-4-carbamoylmethylcoumarin-KHYRSVAW-K(DNP)R + H2O | - |
Homo sapiens | ? | - |
? | |
acetyl-DHYR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-DHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-KDYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
acetyl-KHDR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-KHDR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O | - |
Homo sapiens | acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O | optimal substrate | Homo sapiens | acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
acetyl-KHYR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-KHYR + 7-amino-4-methylcoumarin | - |
? | |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O | suboptimal substrate | Homo sapiens | acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin | - |
? | |
additional information | 7-amido-4-carbamoylmethylcoumarin-KHYRIVAS-K(DNP)R completely inactive | Homo sapiens | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.083 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
0.381 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens | |
0.601 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
1.97 | - |
acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | - |
Homo sapiens | |
2.38 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
6.08 | - |
acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | without ZnCL2 | Homo sapiens | |
6.53 | - |
acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin | with ZnCL2 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000014 | - |
Aprotinin | - |
Homo sapiens | |
0.000005 | - |
placental bikunin | - |
Homo sapiens | |
0.0021 | - |
CuCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
0.0048 | - |
ZnCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
0.01 | - |
NiCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
0.047 | - |
CoCl2 | with acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
0.57 | - |
CoCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
1.15 | - |
CaCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
1.42 | - |
MgCl2 | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
16.4 | - |
NaI | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
21.3 | - |
LiCl | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
22.4 | - |
NaCl | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens | |
26.3 | - |
NaF | with acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin | Homo sapiens |