Cloned (Comment) | Organism |
---|---|
gene KLK14, recombinant expression in Spodoptera frugiperda Sf9 insect cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
YANR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.022 | - |
YASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.025 | - |
YVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.0305 | - |
WVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.034 | - |
WASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.043 | - |
YAAR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.045 | - |
YAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.052 | - |
WAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.318 | - |
VGSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
0.431 | - |
GSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9P0G3 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | pro-kallikrein 14 iss activated with thermolysin | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSLR-4-nitroanilide + H2O | - |
Homo sapiens | GSLR + 4-nitroaniline | - |
? | |
HANR-4-nitroanilide + H2O | - |
Homo sapiens | HANR + 4-nitroaniline | - |
? | |
HASR-4-nitroanilide + H2O | - |
Homo sapiens | HASR + 4-nitroaniline | - |
? | |
HAVR-4-nitroanilide + H2O | - |
Homo sapiens | HAVR + 4-nitroaniline | - |
? | |
HLNR-4-nitroanilide + H2O | - |
Homo sapiens | HLNR + 4-nitroaniline | - |
? | |
HLSR-4-nitroanilide + H2O | - |
Homo sapiens | HLSR + 4-nitroaniline | - |
? | |
HLVR-4-nitroanilide + H2O | - |
Homo sapiens | HLVR + 4-nitroaniline | - |
? | |
HVNR-4-nitroanilide + H2O | - |
Homo sapiens | HVNR + 4-nitroaniline | - |
? | |
HVSR-4-nitroanilide + H2O | - |
Homo sapiens | HVSR + 4-nitroaniline | - |
? | |
HVVR-4-nitroanilide + H2O | - |
Homo sapiens | HVVR + 4-nitroaniline | - |
? | |
MANR-4-nitroanilide + H2O | - |
Homo sapiens | MANR + 4-nitroaniline | - |
? | |
MASR-4-nitroanilide + H2O | - |
Homo sapiens | MASR + 4-nitroaniline | - |
? | |
MAVR-4-nitroanilide + H2O | - |
Homo sapiens | MAVR + 4-nitroaniline | - |
? | |
MLNR-4-nitroanilide + H2O | - |
Homo sapiens | MLNR + 4-nitroaniline | - |
? | |
MLSR-4-nitroanilide + H2O | - |
Homo sapiens | MLSR + 4-nitroaniline | - |
? | |
MLVR-4-nitroanilide + H2O | - |
Homo sapiens | MLVR + 4-nitroaniline | - |
? | |
additional information | determination of substrate and cleavage site specificities of the enzyme using peptide fused to 4-nitroanilide as substrates, molecular modeling of preferred KLK14 substrates. The enzyme KLK14 displays a preference for Tyr and Trp at the P4 site | Homo sapiens | ? | - |
? | |
MVNR-4-nitroanilide + H2O | - |
Homo sapiens | MVNR + 4-nitroaniline | - |
? | |
MVSR-4-nitroanilide + H2O | - |
Homo sapiens | MVSR + 4-nitroaniline | - |
? | |
MVVR-4-nitroanilide + H2O | - |
Homo sapiens | MVVR + 4-nitroaniline | - |
? | |
VGSLR-4-nitroanilide + H2O | - |
Homo sapiens | VGSLR + 4-nitroaniline | - |
? | |
WANR-4-nitroanilide + H2O | - |
Homo sapiens | WANR + 4-nitroaniline | - |
? | |
WASR-4-nitroanilide + H2O | - |
Homo sapiens | WASR + 4-nitroaniline | - |
? | |
WAVR-4-nitroanilide + H2O | - |
Homo sapiens | WAVR + 4-nitroaniline | - |
? | |
WLNR-4-nitroanilide + H2O | - |
Homo sapiens | WLNR + 4-nitroaniline | - |
? | |
WLSR-4-nitroanilide + H2O | - |
Homo sapiens | WLSR + 4-nitroaniline | - |
? | |
WLVR-4-nitroanilide + H2O | - |
Homo sapiens | WLVR + 4-nitroaniline | - |
? | |
WVNR-4-nitroanilide + H2O | - |
Homo sapiens | WVNR + 4-nitroaniline | - |
? | |
WVSR-4-nitroanilide + H2O | - |
Homo sapiens | WVSR + 4-nitroaniline | - |
? | |
WVVR-4-nitroanilide + H2O | - |
Homo sapiens | WVVR + 4-nitroaniline | - |
? | |
YAAR-4-nitroanilide + H2O | - |
Homo sapiens | YAAR + 4-nitroaniline | - |
? | |
YANR-4-nitroanilide + H2O | - |
Homo sapiens | YANR + 4-nitroaniline | - |
? | |
YASR-4-nitroanilide + H2O | - |
Homo sapiens | YASR + 4-nitroaniline | - |
? | |
YAVR-4-nitroanilide + H2O | - |
Homo sapiens | YAVR + 4-nitroaniline | - |
? | |
YLNR-4-nitroanilide + H2O | - |
Homo sapiens | YLNR + 4-nitroaniline | - |
? | |
YLSR-4-nitroanilide + H2O | - |
Homo sapiens | YLSR + 4-nitroaniline | - |
? | |
YLVR-4-nitroanilide + H2O | - |
Homo sapiens | YLVR + 4-nitroaniline | - |
? | |
YVNR-4-nitroanilide + H2O | - |
Homo sapiens | YVNR + 4-nitroaniline | - |
? | |
YVSR-4-nitroanilide + H2O | - |
Homo sapiens | YVSR + 4-nitroaniline | - |
? | |
YVVR-4-nitroanilide + H2O | - |
Homo sapiens | YVVR + 4-nitroaniline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kallikrein-related peptidase 14 | - |
Homo sapiens |
KLK14 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
15.8 | - |
GSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
34.57 | - |
YVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
42.91 | - |
WVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
44.03 | - |
VGSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
53.04 | - |
YANR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
63.24 | - |
WASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
69.37 | - |
YAAR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
83.85 | - |
YASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
93.33 | - |
YAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
97.31 | - |
WAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme structure homology modelling using crystal structure, PDB 2BDG, overview | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
36.6 | - |
GSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
138.3 | - |
VGSLR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
1370 | - |
YVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
1408 | - |
WVSR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
1609 | - |
YAAR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
1880 | - |
WASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
1888 | - |
WAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
2074 | - |
YAVR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3161 | - |
YANR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens | |
3806 | - |
YASR-4-nitroanilide | pH 8.0, 37°C | Homo sapiens |