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Literature summary for 3.4.21.B45 extracted from

  • de Veer, S.J.; Swedberg, J.E.; Parker, E.A.; Harris, J.M.
    Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14 (2012), Biol. Chem., 393, 331-341.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene KLK14, recombinant expression in Spodoptera frugiperda Sf9 insect cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
YANR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.022
-
YASR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.025
-
YVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.0305
-
WVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.034
-
WASR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.043
-
YAAR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.045
-
YAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.052
-
WAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.318
-
VGSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens
0.431
-
GSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P0G3
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification pro-kallikrein 14 iss activated with thermolysin Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSLR-4-nitroanilide + H2O
-
Homo sapiens GSLR + 4-nitroaniline
-
?
HANR-4-nitroanilide + H2O
-
Homo sapiens HANR + 4-nitroaniline
-
?
HASR-4-nitroanilide + H2O
-
Homo sapiens HASR + 4-nitroaniline
-
?
HAVR-4-nitroanilide + H2O
-
Homo sapiens HAVR + 4-nitroaniline
-
?
HLNR-4-nitroanilide + H2O
-
Homo sapiens HLNR + 4-nitroaniline
-
?
HLSR-4-nitroanilide + H2O
-
Homo sapiens HLSR + 4-nitroaniline
-
?
HLVR-4-nitroanilide + H2O
-
Homo sapiens HLVR + 4-nitroaniline
-
?
HVNR-4-nitroanilide + H2O
-
Homo sapiens HVNR + 4-nitroaniline
-
?
HVSR-4-nitroanilide + H2O
-
Homo sapiens HVSR + 4-nitroaniline
-
?
HVVR-4-nitroanilide + H2O
-
Homo sapiens HVVR + 4-nitroaniline
-
?
MANR-4-nitroanilide + H2O
-
Homo sapiens MANR + 4-nitroaniline
-
?
MASR-4-nitroanilide + H2O
-
Homo sapiens MASR + 4-nitroaniline
-
?
MAVR-4-nitroanilide + H2O
-
Homo sapiens MAVR + 4-nitroaniline
-
?
MLNR-4-nitroanilide + H2O
-
Homo sapiens MLNR + 4-nitroaniline
-
?
MLSR-4-nitroanilide + H2O
-
Homo sapiens MLSR + 4-nitroaniline
-
?
MLVR-4-nitroanilide + H2O
-
Homo sapiens MLVR + 4-nitroaniline
-
?
additional information determination of substrate and cleavage site specificities of the enzyme using peptide fused to 4-nitroanilide as substrates, molecular modeling of preferred KLK14 substrates. The enzyme KLK14 displays a preference for Tyr and Trp at the P4 site Homo sapiens ?
-
?
MVNR-4-nitroanilide + H2O
-
Homo sapiens MVNR + 4-nitroaniline
-
?
MVSR-4-nitroanilide + H2O
-
Homo sapiens MVSR + 4-nitroaniline
-
?
MVVR-4-nitroanilide + H2O
-
Homo sapiens MVVR + 4-nitroaniline
-
?
VGSLR-4-nitroanilide + H2O
-
Homo sapiens VGSLR + 4-nitroaniline
-
?
WANR-4-nitroanilide + H2O
-
Homo sapiens WANR + 4-nitroaniline
-
?
WASR-4-nitroanilide + H2O
-
Homo sapiens WASR + 4-nitroaniline
-
?
WAVR-4-nitroanilide + H2O
-
Homo sapiens WAVR + 4-nitroaniline
-
?
WLNR-4-nitroanilide + H2O
-
Homo sapiens WLNR + 4-nitroaniline
-
?
WLSR-4-nitroanilide + H2O
-
Homo sapiens WLSR + 4-nitroaniline
-
?
WLVR-4-nitroanilide + H2O
-
Homo sapiens WLVR + 4-nitroaniline
-
?
WVNR-4-nitroanilide + H2O
-
Homo sapiens WVNR + 4-nitroaniline
-
?
WVSR-4-nitroanilide + H2O
-
Homo sapiens WVSR + 4-nitroaniline
-
?
WVVR-4-nitroanilide + H2O
-
Homo sapiens WVVR + 4-nitroaniline
-
?
YAAR-4-nitroanilide + H2O
-
Homo sapiens YAAR + 4-nitroaniline
-
?
YANR-4-nitroanilide + H2O
-
Homo sapiens YANR + 4-nitroaniline
-
?
YASR-4-nitroanilide + H2O
-
Homo sapiens YASR + 4-nitroaniline
-
?
YAVR-4-nitroanilide + H2O
-
Homo sapiens YAVR + 4-nitroaniline
-
?
YLNR-4-nitroanilide + H2O
-
Homo sapiens YLNR + 4-nitroaniline
-
?
YLSR-4-nitroanilide + H2O
-
Homo sapiens YLSR + 4-nitroaniline
-
?
YLVR-4-nitroanilide + H2O
-
Homo sapiens YLVR + 4-nitroaniline
-
?
YVNR-4-nitroanilide + H2O
-
Homo sapiens YVNR + 4-nitroaniline
-
?
YVSR-4-nitroanilide + H2O
-
Homo sapiens YVSR + 4-nitroaniline
-
?
YVVR-4-nitroanilide + H2O
-
Homo sapiens YVVR + 4-nitroaniline
-
?

Synonyms

Synonyms Comment Organism
kallikrein-related peptidase 14
-
Homo sapiens
KLK14
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
15.8
-
GSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens
34.57
-
YVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
42.91
-
WVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
44.03
-
VGSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens
53.04
-
YANR-4-nitroanilide pH 8.0, 37°C Homo sapiens
63.24
-
WASR-4-nitroanilide pH 8.0, 37°C Homo sapiens
69.37
-
YAAR-4-nitroanilide pH 8.0, 37°C Homo sapiens
83.85
-
YASR-4-nitroanilide pH 8.0, 37°C Homo sapiens
93.33
-
YAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens
97.31
-
WAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens

General Information

General Information Comment Organism
additional information enzyme structure homology modelling using crystal structure, PDB 2BDG, overview Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
36.6
-
GSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens
138.3
-
VGSLR-4-nitroanilide pH 8.0, 37°C Homo sapiens
1370
-
YVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
1408
-
WVSR-4-nitroanilide pH 8.0, 37°C Homo sapiens
1609
-
YAAR-4-nitroanilide pH 8.0, 37°C Homo sapiens
1880
-
WASR-4-nitroanilide pH 8.0, 37°C Homo sapiens
1888
-
WAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens
2074
-
YAVR-4-nitroanilide pH 8.0, 37°C Homo sapiens
3161
-
YANR-4-nitroanilide pH 8.0, 37°C Homo sapiens
3806
-
YASR-4-nitroanilide pH 8.0, 37°C Homo sapiens