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Literature summary for 3.4.21.B41 extracted from

  • Grin, A.; Samaan, S.; Tripathi, M.; Rotondo, F.; Kovacs, K.; Bassily, M.N.; Yousef, G.M.
    Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma (2015), Hum. Pathol., 46, 541-548.
    View publication on PubMed
Search for more literature for 3.4.21.B41

Application

Application Comment Organism
diagnostics enzyme KLK10 is significantly associated with other prognostic markers in gastroesophageal junction adenocarcinoma and Barrett esophagus, including depth of invasion, indicating its potential as independent biomarker Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43240 KLK10
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Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer the enzyme is up-regulated in colorectal cancer Homo sapiens
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esophagus Barrett esophagus with and without dysplasia Homo sapiens
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gastroesophageal junction adenocarcinoma cell early stage Homo sapiens
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additional information significantly increased enzyme expression in dysplastic lesions compared with metaplasia but not between dysplastic lesions and invasive cancers, immunohistochemic analysis, overview Homo sapiens
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Synonyms

Synonyms Comment Organism
KLK10
-
 Homo sapiens
tissue kallikrein-related peptidase 10
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is up-regulated in colorectal cancer, stepwise expression increase from metaplasia to dysplasia and invasive tumors, significantly increased enzyme expression in early invasive cancer, overview up

General Information

General Information Comment Organism
evolution the enzyme is a member of the human kallikrein gene family of secreted serine proteases Homo sapiens
additional information significant correlation between KLK6 and KLK10 expression both at the invasive front and within the main tumor, indicating a collaborative effect Homo sapiens