Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha2-antiplasmin + H2O | Homo sapiens | - |
? | - |
? | |
Gelatin + H2O | Homo sapiens | - |
? | - |
? | |
pre-digested collagen + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell | - |
Homo sapiens | - |
astroglial tumor cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
glioblastoma cell | glioma stem-like cell, isolated from a solid glioblastoma in a long term culture, low expression | Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
U-118MG cell | - |
Homo sapiens | - |
U-138 cell | - |
Homo sapiens | - |
U-343 MG-A cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha2-antiplasmin + H2O | - |
Homo sapiens | ? | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | does not cleave native human collagens, fibronectin or laminin | Homo sapiens | ? | - |
? | |
additional information | FAP-alpha is an endopeptidase cleaving large protein with Gly(2)-Pro(1)-cleaving specificity | Homo sapiens | ? | - |
? | |
pre-digested collagen + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAP-alpha | - |
Homo sapiens |
fibroblast activation protein-alpha | - |
Homo sapiens |
seprase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | FAP-alpha is considerably induced upon differentiation with 10% fetal calf serum, FAP-alpha is elevated in glioblastomas and increases upon tumor stem cell differentiation | up |
General Information | Comment | Organism |
---|---|---|
malfunction | siRNA knockdown of FAP-alpha in a glioma cell line shows decreased invasion through brain extracellular matrix proteoglycan brevican and denatured collagen | Homo sapiens |