Cloned (Comment) | Organism |
---|---|
expressed in 293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetyl-Gly-Pro-boronic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.106 | - |
Ile-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
0.189 | - |
Lys-Ala-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
0.244 | - |
Ala-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
0.245 | - |
Phe-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
0.248 | - |
Gly-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
97000 | - |
SDS-PAGE | Homo sapiens |
100000 | - |
2 * 100000, multiangle light scattering in combination with gel filtration chromatography and interferometric refractometry | Homo sapiens |
200000 | - |
multiangle light scattering in combination with gel filtration chromatography and interferometric refractometry | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
M2-anti-FLAG resin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Gly-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
Ala-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Ala-Pro + 7-amino-4-methylcoumarin | - |
? | |
Ala-Pro-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Ala-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
Arg-Pro-7-amido-4-methylcoumarin + H2O | preferred substrate | Homo sapiens | Arg-Pro + 7-amino-4-methylcoumarin | - |
? | |
benzyloxycarbonyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin + H2O | - |
Homo sapiens | benzyloxycarbonyl-Gly-Pro + 7-amino-4-methyl-3-carbamoylcoumarin | - |
? | |
biotinyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin + H2O | - |
Homo sapiens | biotinyl-Gly-Pro + 7-amino-4-methyl-3-carbamoylcoumarin | - |
? | |
Gln-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gln-Pro + 7-amino-4-methylcoumarin | - |
? | |
Glu-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Glu-Pro + 7-amino-4-methylcoumarin | - |
? | |
Gly-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gly-Pro + 7-amino-4-methylcoumarin | - |
? | |
Gly-Pro-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Gly-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
Ile-Pro-7-amido-4-methylcoumarin + H2O | most preferred substrate | Homo sapiens | Ile-Pro + 7-amino-4-methylcoumarin | - |
? | |
Ile-Pro-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Ile-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
Leu-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Leu-Pro + 7-amino-4-methylcoumarin | - |
? | |
Lys-Ala-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Lys-Ala + 7-amino-4-trifluoromethylcoumarin | - |
? | |
Lys-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Lys-Pro + 7-amino-4-methylcoumarin | - |
? | |
Met-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Met-Pro + 7-amino-4-methylcoumarin | - |
? | |
additional information | shows very weak activity against acetyl-Ser-Pro-7-amido-4-methylcoumarin, Asp-Pro-7-amido-4-methylcoumarin, His-Pro-7-amido-4-methylcoumarin and Asn-Pro-7-amido-4-methylcoumarin, does not cleave succinyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin, Gly-Ala-7-amido-4-methylcoumarin, acetyl-Ala-Pro-7-amido-4-methylcoumarin, acetyl-Asp-Pro-7-amido-4-methylcoumarin, acetyl-Glu-Pro-7-amido-4-methylcoumarin, acetyl-Phe-Pro-7-amido-4-methylcoumarin, acetyl-His-Pro-7-amido-4-methylcoumarin, acetyl-Ile-Pro-7-amido-4-methylcoumarin, acetyl-Lys-Pro-7-amido-4-methylcoumarin, acetyl-Leu-Pro-7-amido-4-methylcoumarin, acetyl-Met-Pro-7-amido-4-methylcoumarin, acetyl-Asn-Pro-7-amido-4-methylcoumarin, acetyl-Pro-Pro-7-amido-4-methylcoumarin, acetyl-Gln-Pro-7-amido-4-methylcoumarin, acetyl-Arg-Pro-7-amido-4-methylcoumarin, acetyl-Thr-Pro-7-amido-4-methylcoumarin, acetyl-Val-Pro-7-amido-4-methylcoumarin, and acetyl-Tyr-Pro-7-amido-4-methylcoumarin | Homo sapiens | ? | - |
? | |
N-formyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin + H2O | - |
Homo sapiens | N-formyl-Gly-Pro + 7-amino-4-methyl-3-carbamoylcoumarin | - |
? | |
N-methyl-Gly-Pro-7-amido-4-methyl-3-carbamoylcoumarin + H2O | - |
Homo sapiens | N-methyl-Gly-Pro + 7-amino-4-methyl-3-carbamoylcoumarin | - |
? | |
Phe-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Phe-Pro + 7-amino-4-methylcoumarin | - |
? | |
Phe-Pro-7-amido-4-trifluoromethylcoumarin + H2O | - |
Homo sapiens | Phe-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
Pro-Pro-7-amido-4-methylcoumarin + H2O | preferred substrate | Homo sapiens | Pro-Pro + 7-amino-4-methylcoumarin | - |
? | |
Ser-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Ser-Pro + 7-amino-4-methylcoumarin | - |
? | |
Thr-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Thr-Pro + 7-amino-4-methylcoumarin | - |
? | |
Tyr-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Tyr-Pro + 7-amino-4-methylcoumarin | - |
? | |
Val-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Val-Pro + 7-amino-4-methylcoumarin | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 100000, multiangle light scattering in combination with gel filtration chromatography and interferometric refractometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
FAP | - |
Homo sapiens |
fibroblast activation protein protease | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
Lys-Ala-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
1.1 | - |
Phe-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
5.6 | - |
Gly-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
6.9 | - |
Ile-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens | |
14.2 | - |
Ala-Pro-7-amido-4-trifluoromethylcoumarin | at 23°C in 50 mM Tris-HCl, 100 mM NaCl, 1 mM EDTA, pH 7.4 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000023 | - |
acetyl-Gly-Pro-boronic acid | - |
Homo sapiens |