Any feedback?
Literature summary for 3.4.21.B28 extracted from
- Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts (1999), J. Biol. Chem., 274, 36505-36512.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| S624A | inactive mutant | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diisopropylfluorophosphate | 50% inhibition at 0.02 mM | Homo sapiens |  |
| phenylmethylsulfonyl fluoride | 50% inhibition at 0.1 mM | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.46 | - |
Ala-Pro-4-trifluoromethylcoumarin-7-amide | pH 7.8, 37°C | Homo sapiens | |
| 0.9 | - |
Lys-Pro-4-trifluoromethylcoumarin-7-amide | pH 7.8, 37°C | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 215000 | - |
SDS-PAGE under nonreducing conditions | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Type I collagen + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | reactive tumor stromal fibroblast and granulation tissue during wound healing | Homo sapiens | - |
| additional information | no activity in normal adult human tissues | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Pro-4-trifluoromethylcoumarin-7-amide + H2O | - |
Homo sapiens | Ala-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
| Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| Lys-Pro-4-trifluoromethylcoumarin-7-amide + H2O | - |
Homo sapiens | Lys-Pro + 7-amino-4-trifluoromethylcoumarin | - |
? | |
| Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FAP | - |
Homo sapiens |
| seprase | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
