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Literature summary for 3.4.21.B26 extracted from
- Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6 (2012), Hum. Reprod., 27, 2766-2774.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| real-time RT-PCR enzyme expression analysis in wild-type and enzyme knockout HEC-1-A cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | stable knockout of the enzyme in HEC-1-A cells by specific siRNA | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
| extracellular | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-integrin-alpha5 + H2O | Homo sapiens | cleavage of the substrate into its heavy and light chains | active integrin-alpha5 + ? | - |
? | |
| pro-integrin-alphaV + H2O | Homo sapiens | cleavage of the substrate into its heavy and light chains | active integrin-alphaV + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92824 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEC-1-A cell | - |
Homo sapiens | - |
| uterine endometrium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-integrin-alpha5 + H2O | cleavage of the substrate into its heavy and light chains | Homo sapiens | active integrin-alpha5 + ? | - |
? | |
| pro-integrin-alphaV + H2O | cleavage of the substrate into its heavy and light chains | Homo sapiens | active integrin-alphaV + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC5/6 | - |
Homo sapiens |
| PC6 | - |
Homo sapiens |
| proprotein convertase 5/6 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme belongs to the Ca2+-dependent proprotein convertase family of enzymes | Homo sapiens |
| malfunction | enzyme-knockout endometrial epithelial cells show reduced capacity to attach to trophoblast spheroids and bind to fibronectin compared with control. Knockdown of the enzyme decreases cell surface presentation of functional integrins-alpha1, alpha2, alpha5, alphaV and alphaVbeta5 | Homo sapiens |
| metabolism | the enzyme in the human endometrium is tightly regulated during receptivity for embryo implantation | Homo sapiens |
| physiological function | pro-integrins-alpha in the endometrial epithelium are post-translationally cleaved by the enzyme into functional subunits for the binding of blastocyst and adhesion of extracellular matrix proteins, the enzyme is responsible for the post-translational cleavage of pro-integrin-alpha5 and integrin-alphaV into their heavy and light chains in HEC-1-A cells. The integrins are transmembrane glycoproteins, some of which play an important role in the adhesive interactions between the trophoblast (blastocyst) and uterine epithelium at implantation | Homo sapiens |
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