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Literature summary for 3.4.21.B26 extracted from

  • Sun, X.; Essalmani, R.; Seidah, N.G.; Prat, A.
    The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model (2009), Mol. Cancer, 8, 73.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B26

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
colon
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 Mus musculus
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duodenum highest expression in the duodenum Mus musculus
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enterocyte in the small intestine PC5/6 is mainly expressed in enterocytes Mus musculus
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ileum
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 Mus musculus
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jejunum
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 Mus musculus
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small intestine PC5/6 is highly expressed in the small intestine Mus musculus
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Synonyms

Synonyms Comment Organism
PC5/6
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 Mus musculus
proprotein convertase 5/6
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 Mus musculus

General Information

General Information Comment Organism
malfunction gene inactivation of PC5/6 leads to lethality at birth, the lack of PC5/6 in enterocytes results in a significantly higher tumor number in the duodenum, the absence of PC5/6 is also associated with a premature mortality of ApcMin/+ mice that harbor a heterozygote multiple intestinal neoplasia mutation in the adenomatous polyposis coli gene Mus musculus
physiological function the proprotein convertase PC5/6 is protective against intestinal tumorigenesis Mus musculus