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Literature summary for 3.4.21.B26 extracted from
- The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates (2008), J. Biol. Chem., 283, 2373-2384.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the activation of PC5A is stimulated by incubation of Y1 cells with adrenocorticotropic hormone or 8-Br-cAMP | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Y1 cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | PC5A is complexed to its prosegment at the plasma membrane | Mus musculus | 16020 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q04592 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADAMTS-4 + H2O | - |
Mus musculus | ? | - |
? |  |
| endothelial lipase + H2O | - |
Mus musculus | ? | - |
? | |
| Lefty protein + H2O | - |
Mus musculus | ? | - |
? | |
| PCSK9 + H2O | - |
Mus musculus | truncated PCSK9-DELTAN218 + ? | - |
? | |
| pyroglutamic acid-RTKR-7-amido-4-methylcoumarin + H2O | - |
Mus musculus | pyroglutamic acid-RTKR + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC5A | - |
Mus musculus |
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