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Literature summary for 3.4.21.B26 extracted from
- The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications (2006), J. Biol. Chem., 281, 30561-30572.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha1-PDX | - |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q92824 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| PCSK9 + H2O | PC5/6A inactivates PCSK9 by cleavage at the motif RFHR218 | Homo sapiens | PCSK9-DELTAN218 + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC5/6A | - |
Homo sapiens |
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