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Literature summary for 3.4.21.B26 extracted from
- RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor (2006), Biochem. J., 400, 209-215.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in GH3-CART cells | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q04592 | precursor | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pro-cocaine- and amphetamine-regulated transcript precursor + H2O | PC5/6A preferentially cleaves the pairs of basic sites, KR/KK, of the CART precursor isoforms | Mus musculus | bioactive pro-cocaine- and amphetamine-regulated transcript I + bioactive pro-cocaine- and amphetamine-regulated transcript II + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC5/6 | - |
Mus musculus |
| prohormone convertase 5/6 | - |
Mus musculus |
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