Literature summary for 3.4.21.B25 extracted from

Akamatsu, T.; Azlina, A.; Javkhlan, P.; Hasegawa, T.; Yao, C.; Hosoi, K.
Salivary gland development: its mediation by a subtilisin-like proprotein convertase, PACE4 (2009), J. Med. Invest., 56, 241-246.

Search for more literature for 3.4.21.B25

Inhibitors

Inhibitors	Comment	Organism	Structure
decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone	potent inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
submandibular gland	PACE4 is intensely expressed in the submandibular epithelium-derived cells including proacinar, terminal tubular, and presumptive ductal cells in the prenatal submandibular gland	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
BMP2 proprotein + H2O	-	Rattus norvegicus	BMP2 + ?	-	?

Synonyms

Synonyms	Comment	Organism
PACE4	-	Rattus norvegicus
SPC4	-	Rattus norvegicus
subtilisin-like proprotein convertase 4	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone suppresses the expression of PACE4	down
Rattus norvegicus	the expression of PACE4 is not suppressed by furin	additional information

General Information

General Information	Comment	Organism
physiological function	PACE4 regulates submandibular gland development via the activation of proproteins involved in salivary branching and/or salivary acinar differentiation	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)