Literature summary for 3.4.21.B25 extracted from

Tsuji, A.; Kanie, H.; Makise, H.; Yuasa, K.; Nagahama, M.; Matsuda, Y.
Engineering of alpha 1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2 residue in stable complex formation of the serpin with proprotein convertase (2007), Protein Eng. Des. Sel., 20, 163-170.

Search for more literature for 3.4.21.B25

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha1-antitrypsin variant Portland	contains a minimal consensus sequence (Arg-X-X-Arg) for efficient cleavage by furin in its reactive site loop	Homo sapiens
alpha1-antitrypsin variant RRRRSA	rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1 and Ala for Leu354 at P2'	Homo sapiens
alpha1-antitrypsin variant RRRRSL	rat alpha-antitrypsin showing substitution of Arg-Arg-Arg-Arg for Ala-Val-Pro-Met352 at P4-P1	Homo sapiens
additional information	not inhibited by alpha1-antitrypsin variant AVRR	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
PACE 4	member of the subtilisin-like proprotein convertase family	Homo sapiens

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Release 2023.1 (January 2023)