Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.B25 extracted from

  • Birsoy, B.; Berg, L.; Williams, P.H.; Smith, J.C.; Wylie, C.C.; Christian, J.L.; Heasman, J.
    XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFb proteins in Xenopus development (2005), Development, 132, 591-602.
    View publication on PubMed
Search for more literature for 3.4.21.B25

Application

Application Comment Organism
additional information maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature TGFbeta proteins in specific sites, it is required for the endogenous mesoderm inducing activity of vegetal cells before gastrulation Xenopus laevis

Cloned(Commentary)

Cloned (Comment) Organism
-
 Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
antisense oligo 5 depletes XPACE4 to 5-10% of control levels; depletes XPACE4 to 5-10% of control levels Xenopus laevis

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm diffusely distributed in the vegetal cytoplasm of full-growth oocytes Xenopus laevis 5737
-
mitochondrion in stage 1 oocytes, XPACE4 localizes to the mitochondrial cloud, at stage 2, the mitochondrial cloud disperses, then XPACE4 mRNA co-localizes with the vegetal cortex where it remains for the rest of oogenesis Xenopus laevis 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000 70000 Northern blot analysis, three different XPACE4 RNA species Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q5G5T8
-
-
Xenopus laevis Q5G5T9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blastula maximum expression of XPACE4 at the early blastula stage Xenopus laevis
-
brain at tailbud stage Xenopus laevis
-
embryo enriched in vegetal masses, with no significant asymmetrical distribution between dorsal and ventral halves Xenopus laevis
-
endoderm at the gastrula stage Xenopus laevis
-
gastrula
-
 Xenopus laevis
-
notochord at tailbud stage Xenopus laevis
-
olfactory bulb at tailbud stage Xenopus laevis
-
oocyte enriched in vegetal halves, with no significant asymmetrical distribution between dorsal and ventral halves Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no cleavage of Xnr5, Derrière or ActivinB pro-proteins Xenopus laevis ?
-
 ?
Vg1 + H2O Vg1 in a TgF beta-related growth factor localized to vegetal blastomers in Xenopus embryos Xenopus laevis ?
-
 ?
Xnr1 + H2O i.e. Nodal-related protein 1 Xenopus laevis ?
-
 ?
Xnr2 + H2O i.e. Nodal-related protein 2 Xenopus laevis ?
-
 ?
Xnr3 + H2O i.e. Nodal-related protein 3 Xenopus laevis ?
-
 ?

Synonyms

Synonyms Comment Organism
XPACE4
-
 Xenopus laevis