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Literature summary for 3.4.21.B25 extracted from
- A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen (1997), Infect. Immun., 65, 3370-3375.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mammalia | role in proteolytic activation of anthrax toxin PA | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| anthrax toxin PA + H2O | contains the sequence RKKR at the cleavage site | Mammalia | ? | - |
? | |
| additional information | enzyme requires basic residues in the -1, -2 and -4 position of the substrate sequence, can recognize RAAR and, to a much lesser extent, KR and RR | Mammalia | ? | - |
? | |
| additional information | role in proteolytic activation of anthrax toxin PA | Mammalia | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PACE4 | - |
Mammalia |
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