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Literature summary for 3.4.21.B25 extracted from

  • Tsuji, A.; Sakurai, K.; Kiyokage, E.; Yamazaki, T.; Koide, S.; Toida, K.; Ishimura, K.; Matsuda, Y.
    Secretory proprotein convertases PACE4 and PC6A are heparin-binding proteins which are localized in the extracellular matrix. Potential role of PACE4 in the activation of proproteins in the extracellular matrix (2003), Biochim. Biophys. Acta, 1645, 95-104.
    View publication on PubMed
Search for more literature for 3.4.21.B25

Activating Compound

Activating Compound Comment Organism Structure
heparin below 1 mg/ml Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
isoform PACE4A-I Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
103000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme binds tightly to heparin and anchors heparan sulfate proteoglycans at the extracellular matrix, role in spatiotemporal regulation of TGFbeta-related factors' biological activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-
syncytiotrophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-Arg-Thr-Lys-Arg-4-methylcoumaryl 7-amide + H2O
-
 Homo sapiens ?
-
 ?
additional information enzyme binds tightly to heparin and anchors heparan sulfate proteoglycans at the extracellular matrix, role in spatiotemporal regulation of TGFbeta-related factors' biological activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PACE4
-
 Homo sapiens