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Literature summary for 3.4.21.B24 extracted from
- Alteration in the processing of the ACRBP/sp32 protein and sperm head/acrosome malformations in proprotein convertase 4 (PCSK4) null mice (2012), Mol. Hum. Reprod., 18, 298-307.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| acrosome | - |
Mus musculus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proform acrosin-binding protein + H2O | Mus musculus | a sperm fertilization molecule located in the acrosomal matrix, the enzyme activates the substrate by processing from a 58.5 kDa precursor to a 27.5 kDa mature form | mature acrosin-binding protein + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P29121 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| germ cell | - |
Mus musculus | - |
| spermatozoon | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| proform acrosin-binding protein + H2O | a sperm fertilization molecule located in the acrosomal matrix, the enzyme activates the substrate by processing from a 58.5 kDa precursor to a 27.5 kDa mature form | Mus musculus | mature acrosin-binding protein + ? | - |
? | |
| proform acrosin-binding protein + H2O | recombinant His-tagged substrate protein, the enzyme activates the substrate by processing from a 58.5 kDa precursor to a 27.5 kDa mature form. Two potential PCSK4 cleavage sites in the ACRBP sequence are KRVR-/-120-123 and KMSR-/-500-503 | Mus musculus | mature acrosin-binding protein + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PCSK4 | - |
Mus musculus |
| proprotein convertase 4 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | proprotein convertase 4 is a member of a family of proprotein convertases that convert inactive precursor proteins into their mature and active forms | Mus musculus |
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