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Literature summary for 3.4.21.B24 extracted from

  • Mishra, P.; Qiu, Q.; Gruslin, A.; Hidaka, Y.; Mbikay, M.; Basak, A.
    In vitro regulatory effect of epididymal serpin CRES on protease activity of proprotein convertase PC4/PCSK4 (2012), Curr. Mol. Med., 12, 1050-1067.
    View publication on PubMed
Search for more literature for 3.4.21.B24

Inhibitors

Inhibitors Comment Organism Structure
cystatin related epididymal spermatogenic dimer i.e. CRES, an epididymal serpin, the recombinant protein inhibits the enzyme activity in vitro in a differential manner depending on its oligomeric state, overview Homo sapiens
cystatin related epididymal spermatogenic monomer i.e. CRES, an epididymal serpin, the recombinant protein inhibits the enzyme activity in vitro in a differential manner depending on its oligomeric state, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform IGF-2 + H2O Homo sapiens
-
 mature IGF-2 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6KW60
-
-
Mus musculus P29121
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
spermatozoon
-
 Homo sapiens
-
trophoblast placental Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-RVRR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Boc-RVRR + 7-amino-4-methylcoumarin
-
 ?
proform IGF-2 + H2O
-
 Homo sapiens mature IGF-2 + ?
-
 ?

Synonyms

Synonyms Comment Organism
PC4
-
 Mus musculus
PC4
-
 Homo sapiens
PCSK4
-
 Mus musculus
PCSK4
-
 Homo sapiens
proprotein convertase PC4/PCSK4
-
 Mus musculus
proprotein convertase PC4/PCSK4
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
 cystatin related epididymal spermatogenic dimer pH and temperature not specified in the publication Homo sapiens
0.1
-
 cystatin related epididymal spermatogenic monomer pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
evolution the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage Mus musculus
evolution the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage Homo sapiens
malfunction PC4 knockout mice exhibit severely impaired male fertility due to premature sperm acrosome reaction Mus musculus
physiological function the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins Mus musculus
physiological function the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins Homo sapiens