Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cystatin related epididymal spermatogenic dimer | i.e. CRES, an epididymal serpin, the recombinant protein inhibits the enzyme activity in vitro in a differential manner depending on its oligomeric state, overview | Homo sapiens | |
cystatin related epididymal spermatogenic monomer | i.e. CRES, an epididymal serpin, the recombinant protein inhibits the enzyme activity in vitro in a differential manner depending on its oligomeric state, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
proform IGF-2 + H2O | Homo sapiens | - |
mature IGF-2 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6KW60 | - |
- |
Mus musculus | P29121 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epididymis | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
spermatozoon | - |
Homo sapiens | - |
trophoblast | placental | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Boc-RVRR-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Boc-RVRR + 7-amino-4-methylcoumarin | - |
? | |
proform IGF-2 + H2O | - |
Homo sapiens | mature IGF-2 + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC4 | - |
Mus musculus |
PC4 | - |
Homo sapiens |
PCSK4 | - |
Mus musculus |
PCSK4 | - |
Homo sapiens |
proprotein convertase PC4/PCSK4 | - |
Mus musculus |
proprotein convertase PC4/PCSK4 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.008 | - |
cystatin related epididymal spermatogenic dimer | pH and temperature not specified in the publication | Homo sapiens | |
0.1 | - |
cystatin related epididymal spermatogenic monomer | pH and temperature not specified in the publication | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage | Mus musculus |
evolution | the enzyme belongs to the 9-member superfamily of mammalian subtilases collectively called proprotein convertases or proprotein convertase subtilisin/kexins that convert inactive precursor proteins into their active mature forms by endoproteolytic cleavage | Homo sapiens |
malfunction | PC4 knockout mice exhibit severely impaired male fertility due to premature sperm acrosome reaction | Mus musculus |
physiological function | the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins | Mus musculus |
physiological function | the enzyme activity plays a crucial role in mammalian fertilization via activation of sperm surface proteins | Homo sapiens |