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Literature summary for 3.4.21.B24 extracted from

  • Basak, A.; Shervani, N.; Kolajova, M.; Cherla, S.; Basak, S.
    Novel reactive site loop derived mini-serpin inhibitors of recombinant proprotein convertase 4 (2009), Adv. Exp. Med. Biol., 611, 105-106.
    View publication on PubMed
Search for more literature for 3.4.21.B24

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression using the Leishmania tarentolae expression system Mammalia

Inhibitors

Inhibitors Comment Organism Structure
CRES peptides development of PC4 inhibitors based onthe CRES reactive site loop, miniserpin inhibitors, sequences, overview Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
acrosome
-
 Mammalia
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mammalia PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mammalia
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage ovarian Mammalia
-
placenta
-
 Mammalia
-
sperm
-
 Mammalia
-
spermatocyte
-
 Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PC4 substrates are growth factors proIGF-1 and proIGF-2, hormonal polypeptides, proPACAP, and surface proteins of the ADAM family, e.g. ADAM1 or fertilin alpha, ADAM2 or fertilin beta, ADAM3 or cyritestin, and ADAM5 Mammalia ?
-
 ?
additional information PC4 cleaves peptide bonds in the sequence R/K/H-X-X/R/K/-R, with X being any amino acid except cysteine, a preferred motif is KXKR Mammalia ?
-
 ?

Synonyms

Synonyms Comment Organism
PC4
-
 Mammalia

General Information

General Information Comment Organism
physiological function PC4 activates everal protein precursors in the secretory pathway of mammalian reproduction system with a vital role in fertilization and sperm maturation Mammalia