Activating Compound | Comment | Organism | Structure |
---|---|---|---|
prodomain rPC4101-116 peptide | at concentrations below 0.001 mM, it enhances PC4-activity depending on concentration (by as much as about 2fold). This activation effect is less significant for a higher substrate concentration and is not noticeable at concentrations above 0.02 mM | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | PC4 inhibitors may find potential therapeutic and clinical applications in male fertility | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
full length and C-terminal truncated rPC4 are expressed using Leishmania tarentolae expression system | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
decanoyl-RVRK-chloromethyl ketone | - |
Rattus norvegicus | |
decanoyl-RVRR-chloromethyl ketone | - |
Rattus norvegicus | |
prodomain rPC4101-116 peptide | strong competitive inhibition | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tert-butyloxycarbonyl-RVRR-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | tert-butyloxycarbonyl-RVRR + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC4 | - |
Rattus norvegicus |
proprotein convertase 4 | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0038 | - |
prodomain rPC4101-116 peptide | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000122 | - |
- |
Rattus norvegicus | decanoyl-RVRK-chloromethyl ketone | |
0.0000166 | - |
- |
Rattus norvegicus | decanoyl-RVRR-chloromethyl ketone |