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Literature summary for 3.4.21.B1 extracted from
- Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis (2008), Thromb. Haemost., 99, 286-289.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| heparin | activates single-chain inactivate zymogen to the two-chain active enzyme | Homo sapiens |  |
| hyaluronic acid | activates single-chain inactivate zymogen to the two-chain active enzyme | Homo sapiens | |
| additional information | FSAP is upregulated by inflammatory mediators | Homo sapiens | |
| RNA | activates single-chain inactivate zymogen to the two-chain active enzyme | Homo sapiens | |
| UpA | - |
Homo sapiens | |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | role in atherosclerosis, contributes to vascular fibroproliferative inflammatory diseases in the context of pericellular proteolysis of the extracellular matrix, growth factor activity and haemostasis | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| FSAP expressed in mouse models of atherosclerosis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E393Q | Marburg II single nucleotide polymorphism. Is not associated with altered enzymatic activity or any other changes in FSAP function | Homo sapiens |
| G534E | Marburg I single nucleotide polymorphism. Has a 5fold lower enzymatic activity. Is a weak activator of pro-uPA, ability to activate factor VII is unchanged. Is strongly linked to late complications of carotid stenosis, direct role in atherosclerosis, risk factor for cardiovascular disease in general, may be also associated with venous thromboembolism | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Alpha1-proteinase inhibitor | - |
Homo sapiens | |
| alpha2-Plasmin inhibitor | - |
Homo sapiens | |
| antithrombin | - |
Homo sapiens | |
| C1 inhibitor | - |
Homo sapiens | |
| additional information | complex formation of FSAP with inhibitors results in rapid internalization of the complexes by low-density lipoprotein receptor-related protein via receptor-mediated endocytosis | Homo sapiens | |
| plasminogen activator inhibitor-1 | - |
Homo sapiens | |
| Protease nexin-1 | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | produces the inactive zymogen | Homo sapiens | - |
| macrophage | - |
Homo sapiens | - |
| monocyte | peripheral blood | Homo sapiens | - |
| additional information | absent from normal vessels, but abundant in unstable atherosclerotic plaques | Homo sapiens | - |
| plasma | circulation of FSAP | Homo sapiens | - |
| vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| factor VII + H2O | - |
Homo sapiens | ? | - |
? | |
| Fibrinogen + H2O | - |
Homo sapiens | ? | - |
? | |
| high molecular weight kininogen + H2O | - |
Homo sapiens | low molecular weight kininogen + bradykinin | - |
? | |
| additional information | single-chain inactive zymogen is autoactivated to the two-chain active enzyme | Homo sapiens | ? | - |
? | |
| platelet-derived growth factor-BB + H2O | - |
Homo sapiens | ? | - |
? | |
| pro-uPA + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| factor VII-activating protease | - |
Homo sapiens |
| FSAP | - |
Homo sapiens |
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