Literature summary for 3.4.21.B1 extracted from

Wygrecka, M.; Morty, R.E.; Markart, P.; Kanse, S.M.; Andreasen, P.A.; Wind, T.; Guenther, A.; Preissner, K.T.
Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome (2007), J. Biol. Chem., 282, 21671-21682.

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Activating Compound

Activating Compound	Comment	Organism	Structure
heparin	-	Homo sapiens
RNA	-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
alpha2-antiplasmin	potently inhibits amidolytic activity of FSAP, but no complex formation can be observed	Homo sapiens
C1 inhibitor	potently inhibits amidolytic activity of FSAP, but no complex formation can be observed	Homo sapiens
additional information	alpha1-proteinase inhibitor and antithrombin III have no effect, no complex formation is observed	Homo sapiens
plasminogen activator inhibitor-1	potently inhibits amidolytic activity of FSAP, FSAP-plasminogen activator inhibitor-1 complex formation. Residue Arg346 is a critical recognition element on plasminogen activator inhibitor-1 for interaction with FSAP. RNA, but not DNA, fragments (more than 400 nucleotides in length) dramatically enhance reactivity of plasminogen activator inhibitor-1 with FSAP. Reactivity can be also enhanced by vitronectin. Also antagonizes FSAP-driven inhibition of vascular smooth muscle cell proliferation	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
64000	-	Western blot analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
by affinity chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	plasminogen activator inhibitor-1-FSAP complexes in addition to high levels of extracellular RNA in bronchoalveolar lavage fluids from patients with acute respiratory distress syndrome	Homo sapiens	-
plasma	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	FSAP circulates as single-chain zymogen in plasma, which is autoactivated to an enzymatically active two-chain form	Homo sapiens	?	-	?
S-2288 + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
factor VII-activating protease	-	Homo sapiens
FSAP	-	Homo sapiens

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Release 2023.1 (January 2023)