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Literature summary for 3.4.21.B1 extracted from

  • Kress, J.A.; Seitz, R.; Dodt, J.; Etscheid, M.
    Induction of intracellular signalling in human endothelial cells by the hyaluronan-binding protease involves two distinct pathways (2006), Biol. Chem., 387, 1275-1283.
    View publication on PubMed
Search for more literature for 3.4.21.B1

Application

Application Comment Organism
medicine proangiogenic potential of HABP, which, in combination with a profibrinolytic activity, directs the physiological function of this plasma protease to processes in which clot lysis, cell motility and neovascularisation are pivotal processes, e.g., in wound healing, tissue repair and tumour progession Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Aprotinin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
basic fibroblast growth factor + H2O HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor. This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2 Homo sapiens ?
-
 ?
fibroblast growth factor receptor 1 + H2O HABP activates the p44/42-dependent MAPK (ERK1/2) signalling cascade independent of the B2-receptor, involving the fibroblast growth factor receptor-1 and basic fibroblast growth factor. This signalling pathway leads to phosphorylation of the kinases Raf, MEK1/2 and ERK1/2 Homo sapiens ?
-
 ?
high molecular weight kininogen + H2O HABP triggers Ca2+ release in HUVEC cells via the bradykinin B2 receptor Homo sapiens low molecular weight kininogen + bradykinin
-
 ?
additional information extracellular activity of HABP affects gene expression level through phosphorylation of two transcription factors, the cAMP responsive element binding protein CREB and the protooncogene c-Myc Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HABP
-
 Homo sapiens
hyaluronan-binding protease
-
 Homo sapiens