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Literature summary for 3.4.21.B1 extracted from

  • Shibamiya, A.; Muhl, L.; Tannert-Otto, S.; Preissner, K.T.; Kanse, S.M.
    Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation (2007), Biochem. J., 404, 45-50.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.B1

Activating Compound

Activating Compound Comment Organism Structure
heparin
-
 Homo sapiens
RNA natural or artificial RNA is an effective cofactor for FSAP mediated platelet-derived growth factor-BB degradation, whereas the effect of DNA is weak Homo sapiens

Application

Application Comment Organism
additional information nucleic acids are cofactors for FSAP-mediated inhibition of platelet-derived growth factor-BB-induced cell proliferation and mitogen-activated protein kinase 44/42 phosphorylation in vascular smooth muscle cells. FSAP protects RNA from the actions of RNase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
platelet-derived growth factor-BB + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
factor VII-activating protease
-
 Homo sapiens
FSAP
-
 Homo sapiens