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Literature summary for 3.4.21.B1 extracted from
- Novel human plasma proteins, IHRP (acute phase protein) and PHBP (serine protease), which bind to glycosaminoglycans (2004), Curr. Med. Chem. Cardiovasc. Hematol. Agents, 2, 239-248.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha2-antiplasmin | - |
Homo sapiens | |
| Aprotinin | - |
Homo sapiens |  |
| C1 inhibitor | - |
Homo sapiens | |
| inter-alpha-trypsin inhibitor | - |
Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 27000 | - |
1 * 50000 + 1 * 27000, active form after cleavage at Arg290 by autocatalytic action, subunits are linked by a disulfide bond | Homo sapiens |
| 50000 | - |
1 * 50000 + 1 * 27000, active form after cleavage at Arg290 by autocatalytic action, subunits are linked by a disulfide bond | Homo sapiens |
| 77000 | - |
proenzyme | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fibrinogen + H2O | Homo sapiens | cleaves the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54 but not the gamma-chain | ? | - |
? | |
| Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Fibrinogen + H2O | cleaves the alpha-chain at multiple sites and the beta-chain between lysine53 and lysine54 but not the gamma-chain | Homo sapiens | ? | - |
? | |
| Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| single chain urokinase type plasminogen activator + H2O | - |
Homo sapiens | two chain urokinase type plasminogen activator | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 50000 + 1 * 27000, active form after cleavage at Arg290 by autocatalytic action, subunits are linked by a disulfide bond | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PHBP | - |
Homo sapiens |
| plasma hyaluronan-binding protein | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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