BRENDA - Enzyme Database
show all sequences of 3.4.21.B1

Regulation mechanism of the serine protease activity of plasma hyaluronan binding protein

Choi-Miura, N.H.; Saito, K.; Takahashi, K.; Yoda, M.; Tomita, M.; Biol. Pharm. Bull. 24, 221-225 (2001)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
Dextran sulfate
enhances autofragmentation and serine protease activity
Homo sapiens
phosphatidylethanolamine
enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
inhibitor C1
C1 inhibitor of the serpin family, forms a complex with the enzyme, 50% inhibition at 0.001 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Protein + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
synthetic substrate
650490
Homo sapiens
N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
650490
Homo sapiens
?
Protein + H2O
-
650490
Homo sapiens
?
-
650490
Homo sapiens
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
Dextran sulfate
enhances autofragmentation and serine protease activity
Homo sapiens
phosphatidylethanolamine
enhances autofragmentation and serine protease activity at 0.001 mg/ml and 0.00001 mg/ml
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
inhibitor C1
C1 inhibitor of the serpin family, forms a complex with the enzyme, 50% inhibition at 0.001 mg/ml
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
Protein + H2O
Homo sapiens
-
?
-
Homo sapiens
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
plasma
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-tert-butoxycarbonyl-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
synthetic substrate
650490
Homo sapiens
N-tert-butoxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin
-
650490
Homo sapiens
?
Protein + H2O
-
650490
Homo sapiens
?
-
650490
Homo sapiens
?
Other publictions for EC 3.4.21.B1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731684
Yoshida
Molecular cloning and tissue d ...
Pagrus major
Comp. Biochem. Physiol. B
165
271-276
2013
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9
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1
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2
2
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717169
Kanse
Factor VII-activating protease ...
Homo sapiens
Arterioscler. Thromb. Vasc. Biol.
32
427-433
2012
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2
2
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717196
Yamamichi
Extracellular histone induces ...
Mus musculus
Biochem. Biophys. Res. Commun.
409
483-488
2011
1
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717319
Yamamoto
Inhibitors of autoactivation o ...
Homo sapiens
Biol. Pharm. Bull.
34
462-470
2011
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1
1
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718425
Sidelmann
Plasma factor VII-activating p ...
Homo sapiens
Thromb. Res.
128
e67-e72
2011
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1
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2
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1
1
1
1
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710611
Parahuleva
Factor Seven Activating Protea ...
Homo sapiens
Thromb. Res.
126
e36-e40
2010
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692366
Muhl
Structure-function analysis of ...
Homo sapiens
FEBS Lett.
583
1994-1998
2009
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1
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2
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692559
Wasmuth
The Marburg I variant (G534E) ...
Homo sapiens
Hepatology
49
775-780
2009
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1
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684801
Parahuleva
Factor Seven Activating Protea ...
Homo sapiens
Atherosclerosis
196
164-171
2008
4
1
1
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1
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3
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8
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1
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4
1
1
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8
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1
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687108
Etscheid
The hyaluronic acid-binding pr ...
Homo sapiens
Int. Immunopharmacol.
8
166-170
2008
5
1
1
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1
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690121
Kanse
Factor VII-activating protease ...
Homo sapiens
Thromb. Haemost.
99
286-289
2008
5
1
1
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2
-
7
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2
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6
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6
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691862
Stephan
Tests for the measurement of f ...
Homo sapiens
Clin. Chem. Lab. Med.
46
1109-1116
2008
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1
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684971
Muhl
Inhibition of PDGF-BB by Facto ...
Homo sapiens
Biochem. J.
404
191-196
2007
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1
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2
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684975
Shibamiya
Nucleic acids potentiate Facto ...
Homo sapiens
Biochem. J.
404
45-50
2007
2
1
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1
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687578
Wygrecka
Plasminogen activator inhibito ...
Homo sapiens
J. Biol. Chem.
282
21671-21682
2007
2
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4
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685438
Kress
Induction of intracellular sig ...
Homo sapiens
Biol. Chem.
387
1275-1283
2006
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668228
Etscheid
The hyaluronan-binding proteas ...
Homo sapiens
Cell. Signal.
17
1486-1494
2005
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668344
Choi-Miura
Novel human plasma proteins, I ...
Homo sapiens
Curr. Med. Chem. Cardiovasc. Hematol. Agents
2
239-248
2004
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4
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2
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1
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1
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1
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650458
Romisch
Factor VII activating protease ...
Homo sapiens
Biol. Chem.
383
1119-1124
2002
3
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6
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1
2
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2
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5
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11
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11
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1
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650470
Etscheid
The hyaluronan-binding serine ...
Homo sapiens
Biol. Chem.
383
1633-1643
2002
3
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650489
Choi-Miura
Identification of the substrat ...
Homo sapiens
Biol. Pharm. Bull.
24
140-143
2001
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5
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650490
Choi-Miura
Regulation mechanism of the se ...
Homo sapiens
Biol. Pharm. Bull.
24
221-225
2001
2
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1
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650492
Choi-Miura
Proteolytic activation and ina ...
Homo sapiens
Biol. Pharm. Bull.
24
448-452
2001
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3
1
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1
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1
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651102
Kannemeier
Factor VII and single-chain pl ...
Homo sapiens
Eur. J. Biochem.
268
3789-3796
2001
1
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1
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1
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1
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1
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-
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1
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-
-
3
1
-
-
2
1
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-
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2
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1
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1
1
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6
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1
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-
-
-
-
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3
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4
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1
1
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1
1
1
1
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6
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1
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1
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3
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1
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1
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1
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