Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Dextran sulfate | strongly accelerates autoactivation, strongest acceleration at 0.02 mg/ml of 5-kDa-dextran sulfate | Homo sapiens | |
heparin | strongly accelerates autoactivation, optimum concentration: 5-10 U/ml, presence of 7.5 U/ml reduces the half-life of the proenzyme from 12 min to 3.5 min | Homo sapiens | |
poly-L-lysine | strongly accelerates autoactivation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha2 antiplasmin | inhibits autoactivation at physiological concentrations | Homo sapiens | |
Aprotinin | potent serine protease inhibitor, inhibits autoactivation at physiological concentrations | Homo sapiens | |
C1 esterase inhibitor | inhibits autoactivation at physiological concentrations | Homo sapiens | |
PPACK | potent serine protease inhibitor, inhibits autoactivation at physiological concentrations | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
proenzyme, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Protein + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | autocatalytic activation | Homo sapiens |
Purification (Comment) | Organism |
---|---|
purification with 6M urea yields the single-chain zymogen, whereas native conditions yield the activated two-chain form | Homo sapiens |
Renatured (Comment) | Organism |
---|---|
complete recovery of enzyme activity within 2 min of incubation at 1 M urea after denaturation in 6M urea | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
coagulation factor FVII + H2O | - |
Homo sapiens | ? | - |
? | |
factor V + H2O | - |
Homo sapiens | ? | - |
? | |
factor VIII + H2O | - |
Homo sapiens | ? | - |
? | |
L-pyroglutamic acid-cyclo-hexylglycine-Arg-para-nitroanilide + H2O | P-3342, fluorogenic substrate | Homo sapiens | ? | - |
? | |
plasminogen activator precursor + H2O | - |
Homo sapiens | ? | - |
? | |
Protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHBSP | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Homo sapiens |