Cloned (Comment) | Organism |
---|---|
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells | hepatitis C virus genotype 1a |
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells | Hepatitis C virus genotype 2a |
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells | Hepatitis C virus genotype 4a |
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells | Hepatitis C virus genotype 5a |
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells | Hepatitis C virus subtype 3a |
Protein Variants | Comment | Organism |
---|---|---|
A156G | virus mutant variant | hepatitis C virus genotype 1a |
A156G | virus mutant variant | Hepatitis C virus genotype 2a |
A156G | virus mutant variant | Hepatitis C virus genotype 4a |
A156G | virus mutant variant | Hepatitis C virus genotype 5a |
A156G | virus mutant variant | Hepatitis C virus subtype 3a |
A156S | virus mutant variant | hepatitis C virus genotype 1a |
A156S | virus mutant variant | Hepatitis C virus genotype 2a |
A156S | virus mutant variant | Hepatitis C virus genotype 4a |
A156S | virus mutant variant | Hepatitis C virus genotype 5a |
A156S | virus mutant variant | Hepatitis C virus subtype 3a |
A156T | virus mutant variant | hepatitis C virus genotype 1a |
A156T | virus mutant variant | Hepatitis C virus genotype 2a |
A156T | virus mutant variant | Hepatitis C virus genotype 4a |
A156T | virus mutant variant | Hepatitis C virus genotype 5a |
A156T | virus mutant variant | Hepatitis C virus subtype 3a |
A156V | virus mutant variant | hepatitis C virus genotype 1a |
A156V | virus mutant variant | Hepatitis C virus genotype 2a |
A156V | virus mutant variant | Hepatitis C virus genotype 4a |
A156V | virus mutant variant | Hepatitis C virus genotype 5a |
A156V | virus mutant variant | Hepatitis C virus subtype 3a |
D168A | virus mutant variant | hepatitis C virus genotype 1a |
D168A | virus mutant variant | Hepatitis C virus genotype 2a |
D168A | virus mutant variant | Hepatitis C virus genotype 4a |
D168A | virus mutant variant | Hepatitis C virus genotype 5a |
D168E | virus mutant variant | hepatitis C virus genotype 1a |
D168E | virus mutant variant | Hepatitis C virus genotype 2a |
D168E | virus mutant variant | Hepatitis C virus genotype 4a |
D168E | virus mutant variant | Hepatitis C virus genotype 5a |
D168G | virus mutant variant | hepatitis C virus genotype 1a |
D168G | virus mutant variant | Hepatitis C virus genotype 2a |
D168G | virus mutant variant | Hepatitis C virus genotype 4a |
D168G | virus mutant variant | Hepatitis C virus genotype 5a |
D168H | virus mutant variant | hepatitis C virus genotype 1a |
D168H | virus mutant variant | Hepatitis C virus genotype 2a |
D168H | virus mutant variant | Hepatitis C virus genotype 4a |
D168H | virus mutant variant | Hepatitis C virus genotype 5a |
D168N | virus mutant variant | hepatitis C virus genotype 1a |
D168N | virus mutant variant | Hepatitis C virus genotype 2a |
D168N | virus mutant variant | Hepatitis C virus genotype 4a |
D168N | virus mutant variant | Hepatitis C virus genotype 5a |
D168V | virus mutant variant | hepatitis C virus genotype 1a |
D168V | virus mutant variant | Hepatitis C virus genotype 2a |
D168V | virus mutant variant | Hepatitis C virus genotype 4a |
D168V | virus mutant variant | Hepatitis C virus genotype 5a |
additional information | for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview | hepatitis C virus genotype 1a |
additional information | for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview | Hepatitis C virus genotype 2a |
additional information | for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview | Hepatitis C virus genotype 4a |
additional information | for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview | Hepatitis C virus genotype 5a |
additional information | for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview | Hepatitis C virus subtype 3a |
Q168A | virus mutant variant | Hepatitis C virus subtype 3a |
Q168E | virus mutant variant | Hepatitis C virus subtype 3a |
Q168G | virus mutant variant | Hepatitis C virus subtype 3a |
Q168H | virus mutant variant | Hepatitis C virus subtype 3a |
Q168N | virus mutant variant | Hepatitis C virus subtype 3a |
Q168V | virus mutant variant | Hepatitis C virus subtype 3a |
R155A | virus mutant variant | hepatitis C virus genotype 1a |
R155A | virus mutant variant | Hepatitis C virus genotype 2a |
R155A | virus mutant variant | Hepatitis C virus genotype 4a |
R155A | virus mutant variant | Hepatitis C virus genotype 5a |
R155A | virus mutant variant | Hepatitis C virus subtype 3a |
R155E | virus mutant variant | hepatitis C virus genotype 1a |
R155E | virus mutant variant | Hepatitis C virus genotype 2a |
R155E | virus mutant variant | Hepatitis C virus genotype 4a |
R155E | virus mutant variant | Hepatitis C virus genotype 5a |
R155E | virus mutant variant | Hepatitis C virus subtype 3a |
R155G | virus mutant variant | hepatitis C virus genotype 1a |
R155G | virus mutant variant | Hepatitis C virus genotype 2a |
R155G | virus mutant variant | Hepatitis C virus genotype 4a |
R155G | virus mutant variant | Hepatitis C virus genotype 5a |
R155G | virus mutant variant | Hepatitis C virus subtype 3a |
R155H | virus mutant variant | hepatitis C virus genotype 1a |
R155H | virus mutant variant | Hepatitis C virus genotype 2a |
R155H | virus mutant variant | Hepatitis C virus genotype 4a |
R155H | virus mutant variant | Hepatitis C virus genotype 5a |
R155H | virus mutant variant | Hepatitis C virus subtype 3a |
R155K | virus mutant variant | hepatitis C virus genotype 1a |
R155K | virus mutant variant | Hepatitis C virus genotype 2a |
R155K | virus mutant variant | Hepatitis C virus genotype 4a |
R155K | virus mutant variant | Hepatitis C virus genotype 5a |
R155K | virus mutant variant | Hepatitis C virus subtype 3a |
R155Q | virus mutant variant | hepatitis C virus genotype 1a |
R155Q | virus mutant variant | Hepatitis C virus genotype 2a |
R155Q | virus mutant variant | Hepatitis C virus genotype 4a |
R155Q | virus mutant variant | Hepatitis C virus genotype 5a |
R155Q | virus mutant variant | Hepatitis C virus subtype 3a |
R155T | virus mutant variant | hepatitis C virus genotype 1a |
R155T | virus mutant variant | Hepatitis C virus genotype 2a |
R155T | virus mutant variant | Hepatitis C virus genotype 4a |
R155T | virus mutant variant | Hepatitis C virus genotype 5a |
R155T | virus mutant variant | Hepatitis C virus subtype 3a |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
asunaprevir | - |
hepatitis C virus genotype 1a | |
asunaprevir | - |
Hepatitis C virus genotype 2a | |
asunaprevir | - |
Hepatitis C virus genotype 4a | |
asunaprevir | - |
Hepatitis C virus genotype 5a | |
asunaprevir | - |
Hepatitis C virus subtype 3a | |
boceprevir | - |
hepatitis C virus genotype 1a | |
boceprevir | - |
Hepatitis C virus genotype 2a | |
boceprevir | - |
Hepatitis C virus genotype 4a | |
boceprevir | - |
Hepatitis C virus genotype 5a | |
boceprevir | - |
Hepatitis C virus subtype 3a | |
deldeprevir | - |
hepatitis C virus genotype 1a | |
deldeprevir | - |
Hepatitis C virus genotype 2a | |
deldeprevir | - |
Hepatitis C virus genotype 4a | |
deldeprevir | - |
Hepatitis C virus genotype 5a | |
deldeprevir | - |
Hepatitis C virus subtype 3a | |
faldaprevir | - |
hepatitis C virus genotype 1a | |
faldaprevir | - |
Hepatitis C virus genotype 2a | |
faldaprevir | - |
Hepatitis C virus genotype 4a | |
faldaprevir | - |
Hepatitis C virus genotype 5a | |
faldaprevir | - |
Hepatitis C virus subtype 3a | |
grazoprevir | - |
hepatitis C virus genotype 1a | |
grazoprevir | - |
Hepatitis C virus genotype 2a | |
grazoprevir | - |
Hepatitis C virus genotype 4a | |
grazoprevir | - |
Hepatitis C virus genotype 5a | |
grazoprevir | - |
Hepatitis C virus subtype 3a | |
additional information | susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview | hepatitis C virus genotype 1a | |
additional information | susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview | Hepatitis C virus genotype 2a | |
additional information | susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview | Hepatitis C virus genotype 4a | |
additional information | susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview | Hepatitis C virus genotype 5a | |
additional information | susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview | Hepatitis C virus subtype 3a | |
paritaprevir | - |
hepatitis C virus genotype 1a | |
paritaprevir | - |
Hepatitis C virus genotype 2a | |
paritaprevir | - |
Hepatitis C virus genotype 4a | |
paritaprevir | - |
Hepatitis C virus genotype 5a | |
paritaprevir | - |
Hepatitis C virus subtype 3a | |
simeprevir | - |
hepatitis C virus genotype 1a | |
simeprevir | - |
Hepatitis C virus genotype 2a | |
simeprevir | - |
Hepatitis C virus genotype 4a | |
simeprevir | - |
Hepatitis C virus genotype 5a | |
simeprevir | - |
Hepatitis C virus subtype 3a | |
telaprevir | - |
hepatitis C virus genotype 1a | |
telaprevir | - |
Hepatitis C virus genotype 2a | |
telaprevir | - |
Hepatitis C virus genotype 4a | |
telaprevir | - |
Hepatitis C virus genotype 5a | |
telaprevir | - |
Hepatitis C virus subtype 3a | |
vaniprevir | - |
hepatitis C virus genotype 1a | |
vaniprevir | - |
Hepatitis C virus genotype 2a | |
vaniprevir | - |
Hepatitis C virus genotype 4a | |
vaniprevir | - |
Hepatitis C virus genotype 5a | |
vaniprevir | - |
Hepatitis C virus subtype 3a |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
hepatitis C virus genotype 1a | - |
HCV, isolate HK6a | - |
hepatitis C virus genotype 1a | - |
HCV, isolate TN | - |
Hepatitis C virus genotype 2a | Q99IB8 | HCV, isolate JFH-1 | - |
Hepatitis C virus genotype 4a | O39929 | HCV, isolate ED43 | - |
Hepatitis C virus genotype 5a | O91936 | HCV, isolate SA13 | - |
Hepatitis C virus subtype 3a | - |
HCV, isolates S52 and 452 | - |
Synonyms | Comment | Organism |
---|---|---|
NS3 protease | - |
hepatitis C virus genotype 1a |
NS3 protease | - |
Hepatitis C virus genotype 2a |
NS3 protease | - |
Hepatitis C virus genotype 4a |
NS3 protease | - |
Hepatitis C virus genotype 5a |
NS3 protease | - |
Hepatitis C virus subtype 3a |