Literature summary for 3.4.21.98 extracted from

Khanizadeh, S.; Ravanshad, M.; Hosseini, S.; Davoodian, P.; Zadeh, A.; Sabahi, F.; Sarvari, J.; Khanlari, Z.; Hasani-Azad, M.
The possible role of NS3 protease activity of hepatitis C virus on fibrogenesis and miR-122 expression in hepatic stellate cells (2016), Acta Virol., 60, 242-248 .

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of wild-type active NS3 and NS3 mutants in LX-2 cells, real-time PCR expression analysis. Protease competent NS3 has a significant fibrogenic impact in LX-2 cells when compared to protease defective NS3 or GFP control plasmids. The expression of miR-122 is downregulated in both versions of the cells transfected with NS3 plasmids irrespective of protease function, impact of protease competent NS3 and protease defective TNS3 on TGF-beta production from LX-2 cells, overview	Hepacivirus C

Cloned (Comment)

Organism

recombinant expression of wild-type active NS3 and NS3 mutants in LX-2 cells, real-time PCR expression analysis. Protease competent NS3 has a significant fibrogenic impact in LX-2 cells when compared to protease defective NS3 or GFP control plasmids. The expression of miR-122 is downregulated in both versions of the cells transfected with NS3 plasmids irrespective of protease function, impact of protease competent NS3 and protease defective TNS3 on TGF-beta production from LX-2 cells, overview

Hepacivirus C

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of mutated non-structural proteins 3 (NS3)	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	HCV	-

Synonyms

Synonyms	Comment	Organism
NS3 protease	-	Hepacivirus C
NS3 protein	-	Hepacivirus C

General Information

General Information	Comment	Organism
malfunction	protease competent NS3 has a significant fibrogenic impact in expressing LX-2 cells when compared to protease defective NS3 or GFP control plasmids	Hepacivirus C
physiological function	possible role of NS3 protease activity of hepatitis C virus in fibrogenesis and miR-122 expression in hepatic stellate cells. Various roles of hepatitis C virus (HCV) NS3 protein in viral pathogenesis are emphasized, especially in the progression of fibrosis and tumors. The expression of miR-122 is downregulated in LX-2 cells transfected with NS3 plasmids, encoding active or defective NS3s, irrespective of protease function. The protease function of NS3 protein is a crucial factor for the induction of hepatic fibrosis but it does not play a complete role in the expression of miR-122. The proteolytically active NS3 protein upregulates TGF-beta1 production	Hepacivirus C