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Literature summary for 3.4.21.98 extracted from

  • Liverton, N.J.; Carroll, S.S.; Dimuzio, J.; Fandozzi, C.; Graham, D.J.; Hazuda, D.; Holloway, M.K.; Ludmerer, S.W.; McCauley, J.A.; McIntyre, C.J.; Olsen, D.B.; Rudd, M.T.; Stahlhut, M.; Vacca, J.P.
    MK-7009, a potent and selective inhibitor of hepatitis C virus NS3/4A protease (2010), Antimicrob. Agents Chemother., 54, 305-311.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli cells Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
BILN-2061
-
Hepacivirus C
MK-7009 i.e. (1R,21S,24S)-21-tert-butyl-N-((1R,2R)-1-[[(cyclopropylsulfonyl)amino]carbonyl]-2-ethylcyclopropyl)-16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracyclo[21.2.1.14,70.06,11]heptacosa-6,8,10-triene-24-carboxamide, potent and selective inhibitor of hepatitis C virus NS3/4A protease Hepacivirus C
SCH-503034
-
Hepacivirus C
VX-950
-
Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Hepacivirus C

Synonyms

Synonyms Comment Organism
NS3
-
Hepacivirus C
NS3 protease
-
Hepacivirus C

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000006
-
MK-7009 NS3/4A genotype 1b Hepacivirus C
0.00000007
-
MK-7009 NS3/4A genotype 1a Hepacivirus C
0.000001
-
MK-7009 NS3/4A genotype 2a Hepacivirus C
0.0000014
-
MK-7009 NS3/4A genotype 2b Hepacivirus C
0.000003
-
BILN-2061 NS3/4A genotype 1b Hepacivirus C
0.0000081
-
BILN-2061 NS3/4A genotype 1a Hepacivirus C
0.000021
-
SCH-503034 NS3/4A genotype 1a Hepacivirus C
0.000021
-
SCH-503034 NS3/4A genotype 2b Hepacivirus C
0.000025
-
SCH-503034 NS3/4A genotype 2a Hepacivirus C
0.000028
-
SCH-503034 NS3/4A genotype 1b Hepacivirus C
0.000042
-
VX-950 NS3/4A genotype 2b Hepacivirus C
0.000054
-
VX-950 NS3/4A genotype 2a Hepacivirus C
0.00007
-
BILN-2061 NS3/4A genotype 2a Hepacivirus C
0.000093
-
VX-950 NS3/4A genotype 1b Hepacivirus C
0.00013
-
VX-950 NS3/4A genotype 1a Hepacivirus C
0.00061
-
BILN-2061 NS3/4A genotype 2b Hepacivirus C