Application | Comment | Organism |
---|---|---|
medicine | NS3 protease blunts the ability of hepatitis C virus to induce IFN-alpha promoter activity by proteolytically cleaving MAVS/IPS-1. Hepatitis C virus blocks the synthetic dsRNA-induced signaling pathway at a point upstream of MAVS/IPS-1 by an NS3-independent mechanism | Hepacivirus C |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BILN2061 | NS3 protease inhibitor, fully restores MAVS/IPS-1-dependent IFN-alpha promoter activity in Hepatitis C virus-infected cells | Hepacivirus C |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MAVS/IPS-1 + H2O | - |
Hepacivirus C | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nonstructural protein 3 | - |
Hepacivirus C |
NS3 protease | - |
Hepacivirus C |