Literature summary for 3.4.21.98 extracted from

Pacini, L.; Bartholomew, L.; Vitelli, A.; Migliaccio, G.
Reporter substrates for assessing the activity of the hepatitis C virus NS3-4A serine protease in living cells (2004), Anal. Biochem., 331, 46-59.

Search for more literature for 3.4.21.98

Protein Variants

Protein Variants	Comment	Organism
analysis	versatile system for monitoring the activity of enzyme in mammalian cells relying on coexpression of enzyme and an artificial substrate containing a reporter domain and an intracellular targeting sequence separated by an enzyme-specific cleavage site	Hepacivirus C

Inhibitors

Inhibitors	Comment	Organism	Structure
N-(tert-butoxycarbonyl)-D-valyl-(4S)-N-(1-carboxy-2-ethenylcyclopropyl)-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-D-prolinamide	50% inhibition of processing of substrate SEAP-1 at 0.00026 mM	Hepacivirus C
N-acetyl-L-alpha-aspartyl-L-alpha-glutamyl-b-phenyl-L-phenylalanyl-L-alpha-glutamyl-N-[1-(carboxycarbonyl)-3,3-difluoropropyl]-3-cyclohexyl-L-alaninamide	50% inhibition of processing of substrate SEAP-1 at 0.0067 mM	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CD8-1 + H2O	synthetic substrate consisting of lymphocyte surface antigen CD8alpha, an enzyme cleavage site and a membrane anchor featuring an endoplasmic reticulum retention sequence	Hepacivirus C	?	-	?
SEAP-1 + H2O	synthetic substrate consisting of alkaline phosphatase, an enzyme cleavage site and a membrane anchor featuring an endoplasmic reticulum retention sequence	Hepacivirus C	?	-	?

Synonyms

Synonyms	Comment	Organism
NS3-4A serine protease	-	Hepacivirus C

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Release 2023.1 (January 2023)