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Literature summary for 3.4.21.98 extracted from

  • Casbarra, A.; Piaz, F.D.; Ingallinella, P.; Orru, S.; Pucci, P.; Pessi, A.; Bianchi, E.
    The effect of prime-site occupancy on the hepatitis C virus NS3 protease structure (2002), Protein Sci., 11, 2102-2112.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.98

Inhibitors

Inhibitors Comment Organism Structure
Asp-Glu-Leu-Ile-L-cyclohexylalanine-aminobutyryl-(Me)Ala-Ser-His-Leu IC50: 5 mM Hepacivirus C
Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-OH IC50: 15 nM Hepacivirus C
Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-Pro-L-cyclohexylalanine-Asp-Leu IC50 below 0.2 nM Hepacivirus C
Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-Pro-Nle-Ser-Leu IC50: 10 nM Hepacivirus C
additional information the effect of prime-site occupancy on the enzyme structure Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C
-
-
-

Synonyms

Synonyms Comment Organism
serine protease NS3
-
 Hepacivirus C

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000002
-
 IC50 below 0.2 nM Hepacivirus C Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-Pro-L-cyclohexylalanine-Asp-Leu
0.00001
-
 IC50: 10 nM Hepacivirus C Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-Pro-Nle-Ser-Leu
0.000015
-
 IC50: 15 nM Hepacivirus C Asp-Glu-Leu-Ile-L-cyclohexylalanine-Cys-OH
5
-
 IC50: 5 mM Hepacivirus C Asp-Glu-Leu-Ile-L-cyclohexylalanine-aminobutyryl-(Me)Ala-Ser-His-Leu