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Literature summary for 3.4.21.97 extracted from

  • Sabit, H.; Dahan, A.; Sun, J.; Provoda, C.J.; Lee, K.D.; Hilfinger, J.H.; Amidon, G.L.
    Cytomegalovirus protease targeted prodrug development (2013), Mol. Pharm., 10, 1417-1424.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine targeting prodrugs for activation by a specific protease encoded by the infectious HCMV pathogen may be achievable. Dipeptide prodrug of ganciclovir, acetyl-L-Gln-L-Ala-ganciclover, is a potential selective prodrug candidate Human betaherpesvirus 5

Protein Variants

Protein Variants Comment Organism
A143T/A144T mutant displays better stability than wild-type and has esterase activity toward specific small ester compounds, e.g., Boc-L-Ala-4-nitrophenol Human betaherpesvirus 5

Organism

Organism UniProt Comment Textmining
Human betaherpesvirus 5
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-L-Gln-L-Ala-gancyclovir + H2O dipeptide prodrugs of ganciclovir Human betaherpesvirus 5 acetyl-L-Gln-L-Ala + ganciclovir
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?

Synonyms

Synonyms Comment Organism
HCMV protease
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Human betaherpesvirus 5