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Literature summary for 3.4.21.94 extracted from
- Dynamic modulation of PC2-mediated precursor processing by 7B2: preferential effect on glucagon synthesis (2011), J. Biol. Chem., 286, 42504-42513.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| small neuroendocrine protein 7B2 | 7B2 overexpression decreases the secretion and increases the activity of PC2 within alpha-TC6 cells | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proglucagon + H2O | Mus musculus | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Proglucagon + H2O | - |
Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC2 | - |
Mus musculus |
| prohormone convertase 2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | proglucagon cleavage has a greater dependence on PC2 activity than other precursors (e.g. proopiomelanocortin) and 7B2-dependent routing of PC2 to secretory granules is cell line-specific | Mus musculus |
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