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Literature summary for 3.4.21.94 extracted from

  • Zhan, S.; Zhao, H.; J White, A.; Minami, M.; Pignataro, G.; Yang, T.; Zhu, X.; Lan, J.; Xiong, Z.; Steiner, D.F.; Simon, R.P.; Zhou, A.
    Defective neuropeptide processing and ischemic brain injury: a study on proprotein convertase 2 and its substrate neuropeptide in ischemic brains (2009), J. Cereb. Blood Flow Metab., 29, 698-706.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.94

Inhibitors

Inhibitors Comment Organism Structure
CT peptide a PC2-specific inhibitor Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
 x * 75000, pro-PC2 form, SDS-PAGE, x * 64000, mature PC2 form, SDS-PAGE Rattus norvegicus
75000
-
 x * 75000, pro-PC2 form, SDS-PAGE, x * 64000, mature PC2 form, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain healthy and ischemic Rattus norvegicus
-
cell culture
-
 Rattus norvegicus
-
cerebral cortex high PC2 protein content at early ischeic reperfusion hour, which decreases with reperfusion time Rattus norvegicus
-
neuronal cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dynorphin-A(1-8) + H2O
-
 Rattus norvegicus ?
-
 ?
L-pGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus L-pGlu-Arg-Thr-Lys-Arg + 7-amino-4-methylcoumarin
-
 ?

Subunits

Subunits Comment Organism
? x * 75000, pro-PC2 form, SDS-PAGE, x * 64000, mature PC2 form, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
PC2
-
 Rattus norvegicus
proprotein convertase 2
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 assay at Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus transient upregulation of the mRNA level for PC2 in cerebral cortex at an early reperfusion h in a cerebral ischemia model in rats up

General Information

General Information Comment Organism
malfunction PC2 activity is reduced in ischemic brains, brain ischemia attenuates PC2 and PC2-mediated neuropeptide processing. This attenuation may play a role in the pathology of ischemic brain injury. Intracerebroventricular administration of synthetic PC2 substrate dynorphin-A(1-8) significantly reduces the extent of ischemic brain injury, overview Rattus norvegicus
physiological function PC2 mediates neuropeptide processing in the brain Rattus norvegicus