Application | Comment | Organism |
---|---|---|
medicine | transplantation of PC2-expressing alpha-cells increases plasma glucagon levels and causes mild fasting hyperglycemia, impairs glucose tolerance, and alpha-cell hypoplasia. PC2-expressing alpha-cells neither prevent streptozotocin-induced hyperglycemia nor increased beta-cell proliferation in the context of type 1 diabetes | Mus musculus |
Cloned (Comment) | Organism |
---|---|
transplantation of encapsulated PC2-expressing alpha TC-1 cells with PC1/3-expressing alpha TCdeltaPC2 cells in normal mice and low-dose streptozotocin-treated mice | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
CD-1 mice and C57B/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | alpha TC1 cells express PC2, alpha TCdeltaPC2 cells do not express bioactive PC2 | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
proglucagon + H2O | - |
Mus musculus | glucagon | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PC2 | - |
Mus musculus |
prohormone convertase 2 | - |
Mus musculus |