Literature summary for 3.4.21.94 extracted from

Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain (2007), Neuroscience, 147, 403-418.

Search for more literature for 3.4.21.94

Application

Application	Comment	Organism
additional information	PC2 may be a potential target for the maturation of somatostatin	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Rattus norvegicus	5737	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
68000	-	x * 75000, proPC2, Western blot analysis. x * 68000, mature PC2, Western blot analysis	Rattus norvegicus
75000	-	x * 75000, proPC2, Western blot analysis. x * 68000, mature PC2, Western blot analysis	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	adult male Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
cerebral cortex	colocalization with somatostatin, carboxypeptidase-E and PC1 in pyramidal and non-pyramidal neurons. PC2 exhibits 30% colocalization with somatostatin and 44% with carboxypeptidase-E	Rattus norvegicus	-
hippocampus	PC2 expressed in all the regions with similar levels	Rattus norvegicus	-
additional information	in the striatum, PC2 is uniformly expressed. In addition to neurons, some nerve fibers in striatum are also PC2 positive. PC2 exhibits 19% colocalization with somatostatin and 44% with carboxypeptidase-E in the striatum	Rattus norvegicus	-
neuron	PC2 is confined to neurons of the deeper layer. Interneurons display stronger PC2 expression than projection neurons	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
somatostatin + H2O	PC2 may function as sorting element for somatostatin for its maturation and processing to appropiate targets	Rattus norvegicus	?	-	?

Subunits

Subunits	Comment	Organism
?	x * 75000, proPC2, Western blot analysis. x * 68000, mature PC2, Western blot analysis	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
PC2	-	Rattus norvegicus
prohormone convertase 2	-	Rattus norvegicus

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Release 2023.1 (January 2023)