Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation | Rattus norvegicus | 5794 | - |
lysosome | in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation. Co-localization of PC1/3 and Toll-like receptor 4 is found upon lipopolysaccharide stimulation | Rattus norvegicus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Rattus norvegicus | - |
NR-8383 cell | - |
Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | downregulation of convertase PC1/3 by shRNA produces a phenotype in NR-8383 cells similar to isolated peritoneal macrophages. PC1/3 shRNA induces changes in the cellular organization and expression of the specific trafficking regulator RAB GTPase. NR-8383 cells down-regulated for PC1/3 present an abnormal cytokine secretion profile | Rattus norvegicus |