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Literature summary for 3.4.21.93 extracted from

  • Gagnon, H.; Refaie, S.; Gagnon, S.; Desjardins, R.; Salzet, M.; Day, R.
    Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion (2013), PLoS ONE, 8, e61557.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation Rattus norvegicus 5794
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lysosome in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation. Co-localization of PC1/3 and Toll-like receptor 4 is found upon lipopolysaccharide stimulation Rattus norvegicus 5764
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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 Rattus norvegicus
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NR-8383 cell
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 Rattus norvegicus
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General Information

General Information Comment Organism
physiological function downregulation of convertase PC1/3 by shRNA produces a phenotype in NR-8383 cells similar to isolated peritoneal macrophages. PC1/3 shRNA induces changes in the cellular organization and expression of the specific trafficking regulator RAB GTPase. NR-8383 cells down-regulated for PC1/3 present an abnormal cytokine secretion profile Rattus norvegicus