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Literature summary for 3.4.21.93 extracted from

  • Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
    Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain (2007), Neuroscience, 147, 403-418.
    View publication on PubMed
Search for more literature for 3.4.21.93

Application

Application Comment Organism
additional information PC1 may be a potential target for the maturation of somatostatin Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
87000
-
 x * 87000, Western blot analysis Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 adult male Sprague-Dawley rats
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
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cerebral cortex colocalization with somatostatin, carboxypeptidase-E and PC2 in pyramidal and non-pyramidal neurons. Colocalization with carboxypeptidase-E confined to pyramidal neurons of deeper layer. PC1 exhibits 26% colocalization with somatostatin and 34% with carboxypeptidase-E Rattus norvegicus
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hippocampus lower expression in comparison to the cortex and striatum. In the hippocampal regions CA1 and CA2 all somatostatin positive interneurons moderately colocalize with PC1, no colocalization of PC1 with carboxypeptidase-E. Weak colocalization between PC1 and carboxypeptidase-E confined to neurons of the pyramidal layer Rattus norvegicus
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neuron expressed in larger neurons (interneurons) of the striatum. Either weak or no expression in smaller neurons. Colocalization with somatostatin or carboxypeptidase-E confined to interneurons. PC1 exhibits 11% colocalization with somatostatin and 29% with carboxypeptidase-E in the striatum Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
somatostatin + H2O PC1 may function as sorting element for somatostatin for its maturation and processing to appropiate targets Rattus norvegicus ?
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 ?

Subunits

Subunits Comment Organism
? x * 87000, Western blot analysis Rattus norvegicus

Synonyms

Synonyms Comment Organism
PC1
-
 Rattus norvegicus
prohormone convertase 1
-
 Rattus norvegicus