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Literature summary for 3.4.21.93 extracted from

  • Shen, X.; Li, Q.L.; Brent, G.A.; Friedman, T.C.
    Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements (2004), J. Mol. Endocrinol., 33, 21-33.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information hypothyroidism increases enzyme expression in hypothalamus and cerebral cortex Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of PC1 using a human PC1 promoter in PC1-deficient GH3 cells, the large region of the PC1 promoter contains negative thyroid hormone response elements which interact with triiodothyronine for regulation of anterior pituitary PC1 mRNA levels, interaction analysis, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information hyperthyroidism suppresses enzyme expression in hypothalamus and cerebral cortex Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
anterior pituitary gland
-
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
cerebral cortex
-
Rattus norvegicus
-
hypothalamus
-
Rattus norvegicus
-
additional information not in the hippocampus Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
PC1
-
Rattus norvegicus
prohormone convertase 1
-
Rattus norvegicus