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Literature summary for 3.4.21.93 extracted from

  • Dey, A.; Norrbom, C.; Zhu, X.; Stein, J.; Zhang, C.; Ueda, K.; Steiner, D.F.
    Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone (2004), Endocrinology, 145, 1961-1971.
    View publication on PubMed
Search for more literature for 3.4.21.93

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
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 Mus musculus 5794
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secretory granule
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 Mus musculus 30141
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-growth hormone-releasing hormone + H2O Mus musculus PC1/3 and furin, EC 3.4.21.75, are major processing enzymes, processing overview growth hormone-releasing hormone + pro-peptide of growth hormone-releasing hormone
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AtT-20 cell
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 Mus musculus
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beta-TC3 cell derived from pancreatic islets Mus musculus
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additional information PC1/3 subcellular localization analysis Mus musculus
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neuroendocrine cell
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 Mus musculus
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pancreatic islet
-
 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-growth hormone-releasing hormone + H2O PC1/3 and furin, EC 3.4.21.75, are major processing enzymes, processing overview Mus musculus growth hormone-releasing hormone + pro-peptide of growth hormone-releasing hormone
-
 ?
pro-growth hormone-releasing hormone + H2O pro-GHRH, processing, cleavage of C-terminal -RXRXXR-/-, cleavage site specificity determination by substrate mutational analysis, activity with pro-GHRH mutants R8A, R11A, and Q10R, overview Mus musculus growth hormone-releasing hormone + pro-peptide of growth hormone-releasing hormone
-
 ?

Synonyms

Synonyms Comment Organism
PC1/3
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 Mus musculus
prohormone convertase 1/3
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 Mus musculus