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Literature summary for 3.4.21.93 extracted from

  • Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
    Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide (2004), Diabetes, 53, 141-148.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
co-expression of PC1/3 and rat pro-islet amyloid polypeptide, proIAPP, in GH3 cells lacking the enzyme, leads to cleavage of recombinant proIAPP Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information PC1/3 null mutant mice show C-terminally impaired but not completely blocked proIAPP processing, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-islet amyloid polypeptide + H2O Mus musculus precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the C- and N-terminus islet amyloid polypeptide + pro-peptides of islet amyloid polypeptide
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-islet amyloid polypeptide + H2O precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the C- and N-terminus Mus musculus islet amyloid polypeptide + pro-peptides of islet amyloid polypeptide
-
?

Synonyms

Synonyms Comment Organism
PC1/3
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Mus musculus
prohormone convertase 1/3
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Mus musculus