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Literature summary for 3.4.21.93 extracted from
- Proprotein convertase PC3 is not a transmembrane protein (2005), Biochemistry, 44, 5339-5345.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type and mutant PC3 in COS-1 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of an PC3 containing a 19 amino-acid transmembrane sequence, and/or a C-terminal glycosylation tag, the C-terminal extension is exposed to the endoplasmic reticulum lumen, overview | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | peripherally attached to the secretory granule membrane, the enzyme is no transmembrane protein, subcellular localization analysis, overview | Homo sapiens | 16020 | - |
| additional information | the enzyme is transferred through the endoplasmic reticulum membrane | Homo sapiens | - |
- |
| secretory granule | peripherally attached to the granule membrane | Homo sapiens | 30141 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the catalytic domain of PC1 contains two potential N-glycosylation sites | Homo sapiens |
| additional information | the PC3 C-terminus is not accessible to cytosolic protein kinase, recombinant PC3 is not phosphorylated in transfected COS-1 cells at a C-terminal phosphorylation site | Homo sapiens |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | PC3 domain organization, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PC1 | - |
Homo sapiens |
| PC3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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