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Literature summary for 3.4.21.93 extracted from
- Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1 (2001), J. Biol. Chem., 276, 32720-32728.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | highly specific and potent PC1 inhibitors proSAAS-(235-246) and proSAAS-(235-244) may be useful in development of an effective affinity procedure for the purification of PC1 | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| full-length cDNA | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dSAAS-(235-244) | - |
Mus musculus |  |
| PenLen (rSAAS-(221-2546)) | - |
Mus musculus | |
| proSAAS peptide | - |
Mus musculus | |
| SAAS-(235-244) | - |
Mus musculus | |
| SAAS-(235-246) | - |
Mus musculus | |
| SAAS-(235-246)P1'A | - |
Mus musculus | |
| SAAS-(235-246)P10A | - |
Mus musculus | |
| SAAS-(235-246)P1A | - |
Mus musculus | |
| SAAS-(235-246)P1K | - |
Mus musculus | |
| SAAS-(235-246)P2'A | - |
Mus musculus | |
| SAAS-(235-246)P2A | - |
Mus musculus | |
| SAAS-(235-246)P3A | - |
Mus musculus | |
| SAAS-(235-246)P3AP5A | - |
Mus musculus | |
| SAAS-(235-246)P4A | - |
Mus musculus | |
| SAAS-(235-246)P4K | - |
Mus musculus | |
| SAAS-(235-246)P5A | - |
Mus musculus | |
| SAAS-(235-246)P6A | - |
Mus musculus | |
| SAAS-(235-246)P8A | - |
Mus musculus | |
| SAAS-(235-246)P9A | - |
Mus musculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
- |
Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pGlu-Arg-Thr-Lys-Arg-4-methyl-coumarin 7-amide | - |
Mus musculus | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000009 | - |
SAAS-(235-244) | pH 6.5, 37°C | Mus musculus | |
| 0.000051 | - |
SAAS-(235-246) | pH 6.5, 37°C | Mus musculus | |
| 0.000058 | - |
SAAS-(235-246)P6A | pH 6.5, 37°C | Mus musculus | |
| 0.000119 | - |
PenLen (rSAAS-(221-246)) | pH 6.5, 37°C | Mus musculus | |
| 0.000143 | - |
SAAS-(235-246)P8A | pH 6.5, 37°C | Mus musculus | |
| 0.000172 | - |
SAAS-(235-246)P5A | pH 6.5, 37°C | Mus musculus | |
| 0.000177 | - |
SAAS-(235-246)P10A | pH 6.5, 37°C | Mus musculus | |
| 0.000286 | - |
SAAS-(235-246)P4A | pH 6.5, 37°C | Mus musculus | |
| 0.000293 | - |
SAAS-(235-246)P2'A | pH 6.5, 37°C | Mus musculus | |
| 0.00036 | - |
SAAS-(235-246)P3A | pH 6.5, 37°C | Mus musculus | |
| 0.000737 | - |
SAAS-(235-246)P9A | pH 6.5, 37°C | Mus musculus | |
| 0.001024 | - |
SAAS-(235-246)P1'A | pH 6.5, 37°C | Mus musculus | |
| 0.00153 | - |
SAAS-(235-246)P1K | pH 6.5, 37°C | Mus musculus | |
| 0.0137 | - |
SAAS-(235-246)P3AP5A | pH 6.5, 37°C | Mus musculus | |
| 0.122 | - |
dSAAS-(235-244) | pH 6.5, 37°C | Mus musculus | |
| 0.1775 | - |
SAAS-(235-246)P4K | pH 6.5, 37°C | Mus musculus | |
| 0.509 | - |
SAAS-(235-246)P1A | pH 6.5, 37°C | Mus musculus | |
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