Literature summary for 3.4.21.92 extracted from

Ni, T.; Ye, F.; Liu, X.; Zhang, J.; Liu, H.; Li, J.; Zhang, Y.; Sun, Y.; Wang, M.; Luo, C.; Jiang, H.; Lan, L.; Gan, J.; Zhang, A.; Zhou, H.; Yang, C.G.
Characterization of gain-of-function mutant provides new insights into ClpP structure (2016), ACS Chem. Biol., 11, 1964-1972 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant Y63A displays promoted self-activated proteolysis, which is a result of an enlarged entrance pore	Staphylococcus aureus

Protein Variants

Protein Variants	Comment	Organism
Y63A	gain-of-function mutant, inhibits staphylococcal growth. The mutant becomes an uncontrolled protease that actively hydrolyzes cell division protein FtsZ in vitro. Expression of mutant phenocopies treatment with acyldepsipeptides, inhibition of cell division occurs as does showing sterilizing with rifampicin antibiotics	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	P63786	-	-
Staphylococcus aureus MW2	P63786	-	-

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Release 2023.1 (January 2023)