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Literature summary for 3.4.21.92 extracted from

  • Personne, Y.; Brown, A.; Schuessler, D.; Parish, T.
    Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities (2013), PLoS ONE, 8, e60228.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WPC3 protease subunit ClpP2
-
Mycobacterium tuberculosis P9WPC5 protease subunit ClpP1
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Mycobacterium tuberculosis H37Rv P9WPC3 protease subunit ClpP2
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Mycobacterium tuberculosis H37Rv P9WPC5 protease subunit ClpP1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
LacZ + H2O
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Mycobacterium tuberculosis ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
LacZ + H2O
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Mycobacterium tuberculosis H37Rv ? proteolytic subunit ClpP2 over-expression induces degradation of untagged LacZ ?
additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis ?
-
?
additional information the SsrA tag directs proteins to degradation by both ClpP1 and ClpP2. The terminal three residues of the ssrA-tag sequence are LAA. A LAA-tag is sufficient to direct proteins into the degradation pathway Mycobacterium tuberculosis H37Rv ?
-
?
SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis ?
-
?
SsrA-tagged LacZ + H2O both proteolytic subunits ClpP1 and ClpP2 degrade SsrA-tagged LacZ Mycobacterium tuberculosis H37Rv ?
-
?

Synonyms

Synonyms Comment Organism
ATP-dependent Clp protease proteolytic subunit 1
-
Mycobacterium tuberculosis
ATP-dependent Clp protease proteolytic subunit 2
-
Mycobacterium tuberculosis
ClpP1
-
Mycobacterium tuberculosis
ClpP2
-
Mycobacterium tuberculosis

Expression

Organism Comment Expression
Mycobacterium tuberculosis proteolytic subunits ClpP1 and ClpP2 are co-expressed under normal growth conditions with a single promoter region for the clpP1P2 operon additional information