Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
central competence regulator sigmax + H2O | Streptococcus thermophilus | adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner | ? | - |
? | |
central competence regulator sigmax + H2O | Streptococcus thermophilus ATCC BAA-250 | adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus thermophilus | Q5M6G1 | - |
- |
Streptococcus thermophilus ATCC BAA-250 | Q5M6G1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
central competence regulator sigmax + H2O | adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner | Streptococcus thermophilus | ? | - |
? | |
central competence regulator sigmax + H2O | adaptor protein MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner | Streptococcus thermophilus ATCC BAA-250 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CplC | - |
Streptococcus thermophilus |
General Information | Comment | Organism |
---|---|---|
physiological function | adaptor protein MecA specifically interacts with both central competence regulator sigmax and protease ClpC, suggesting the formation of a ternary sigmaX-MecA-ClpC complex. MecA ultimately targets sigmaX for its degradation by the ClpCP protease in an ATP-dependent manner. A short sequence of 18 amino acids in the N-terminal domain of sigmaX is essential for the interaction with MecA and subsequent sigmaX degradation. Increased transformability of a MecA-deficient strain in the presence of subinducing SigX-inducing peptide concentrations suggests that the MecA-ClpCP proteolytic complex acts as an additional locking device to prevent competence under inappropriate conditions | Streptococcus thermophilus |